GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity.
Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Al Rijjal D, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J, Dai FF, Wheeler MB.
Untereiner A, et al. Among authors: wong a.
FASEB J. 2019 Mar;33(3):3968-3984. doi: 10.1096/fj.201801397R. Epub 2018 Dec 3.
FASEB J. 2019.
PMID: 30509117
Taken together, this study provides new mechanistic insight into the proliferative nature of GABA but suggests that beta-cell compensation associated with prediabetes overlaps with, and negates, its proliferative effects.-Untereiner, A., Abdo, S., Bhattacharjee, A., …
Taken together, this study provides new mechanistic insight into the proliferative nature of GABA but suggests that beta-cell compensation a …