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223 results

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Page 1
Proteomic discovery of chemical probes that perturb protein complexes in human cells.
Lazear MR, Remsberg JR, Jaeger MG, Rothamel K, Her HL, DeMeester KE, Njomen E, Hogg SJ, Rahman J, Whitby LR, Won SJ, Schafroth MA, Ogasawara D, Yokoyama M, Lindsey GL, Li H, Germain J, Barbas S, Vaughan J, Hanigan TW, Vartabedian VF, Reinhardt CJ, Dix MM, Koo SJ, Heo I, Teijaro JR, Simon GM, Ghosh B, Abdel-Wahab O, Ahn K, Saghatelian A, Melillo B, Schreiber SL, Yeo GW, Cravatt BF. Lazear MR, et al. Among authors: won sj. Mol Cell. 2023 May 18;83(10):1725-1742.e12. doi: 10.1016/j.molcel.2023.03.026. Epub 2023 Apr 20. Mol Cell. 2023. PMID: 37084731
Assigning functionality to cysteines by base editing of cancer dependency genes.
Li H, Ma T, Remsberg JR, Won SJ, DeMeester KE, Njomen E, Ogasawara D, Zhao KT, Huang TP, Lu B, Simon GM, Melillo B, Schreiber SL, Lykke-Andersen J, Liu DR, Cravatt BF. Li H, et al. Among authors: won sj. Nat Chem Biol. 2023 Nov;19(11):1320-1330. doi: 10.1038/s41589-023-01428-w. Epub 2023 Oct 2. Nat Chem Biol. 2023. PMID: 37783940 Free PMC article.
Expanding the ligandable proteome by paralog hopping with covalent probes.
Zhang Y, Liu Z, Hirschi M, Brodsky O, Johnson E, Won SJ, Nagata A, Petroski MD, Majmudar JD, Niessen S, VanArsdale T, Gilbert AM, Hayward MM, Stewart AE, Nager AR, Melillo B, Cravatt B. Zhang Y, et al. Among authors: won sj. bioRxiv [Preprint]. 2024 Jan 19:2024.01.18.576274. doi: 10.1101/2024.01.18.576274. bioRxiv. 2024. PMID: 38293178 Free PMC article. Preprint.
Protein depalmitoylases.
Won SJ, Cheung See Kit M, Martin BR. Won SJ, et al. Crit Rev Biochem Mol Biol. 2018 Feb;53(1):83-98. doi: 10.1080/10409238.2017.1409191. Epub 2017 Dec 14. Crit Rev Biochem Mol Biol. 2018. PMID: 29239216 Free PMC article. Review.
Molecular Mechanism for Isoform-Selective Inhibition of Acyl Protein Thioesterases 1 and 2 (APT1 and APT2).
Won SJ, Davda D, Labby KJ, Hwang SY, Pricer R, Majmudar JD, Armacost KA, Rodriguez LA, Rodriguez CL, Chong FS, Torossian KA, Palakurthi J, Hur ES, Meagher JL, Brooks CL 3rd, Stuckey JA, Martin BR. Won SJ, et al. ACS Chem Biol. 2016 Dec 16;11(12):3374-3382. doi: 10.1021/acschembio.6b00720. Epub 2016 Oct 31. ACS Chem Biol. 2016. PMID: 27748579 Free PMC article.
α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway.
Oliveira da Silva MI, Santejo M, Babcock IW, Magalhães A, Minamide LS, Won SJ, Castillo E, Gerhardt E, Fahlbusch C, Swanson RA, Outeiro TF, Taipa R, Ruff M, Bamburg JR, Liz MA. Oliveira da Silva MI, et al. Among authors: won sj. Cell Death Dis. 2024 Apr 13;15(4):264. doi: 10.1038/s41419-024-06630-9. Cell Death Dis. 2024. PMID: 38615035 Free PMC article.
Redirecting the pioneering function of FOXA1 with covalent small molecules.
Won SJ, Zhang Y, Reinhardt CJ, MacRae NS, DeMeester KE, Njomen E, Hargis LM, Remsberg JR, Melillo B, Cravatt BF, Erb MA. Won SJ, et al. bioRxiv [Preprint]. 2024 Mar 21:2024.03.21.586158. doi: 10.1101/2024.03.21.586158. bioRxiv. 2024. PMID: 38562719 Free PMC article. Preprint.
223 results