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Disrupted CaV1.2 selectivity causes overlapping long QT and Brugada syndrome phenotypes in the CACNA1C-E1115K iPS cell model.
Kashiwa A, Makiyama T, Kohjitani H, Maurissen TL, Ishikawa T, Yamamoto Y, Wuriyanghai Y, Gao J, Huang H, Imamura T, Aizawa T, Nishikawa M, Chonabayashi K, Mishima H, Ohno S, Toyoda F, Sato S, Yoshiura KI, Takahashi K, Yoshida Y, Woltjen K, Horie M, Makita N, Kimura T. Kashiwa A, et al. Among authors: woltjen k. Heart Rhythm. 2023 Jan;20(1):89-99. doi: 10.1016/j.hrthm.2022.08.021. Epub 2022 Aug 23. Heart Rhythm. 2023. PMID: 36007726
Recapitulating the human segmentation clock with pluripotent stem cells.
Matsuda M, Yamanaka Y, Uemura M, Osawa M, Saito MK, Nagahashi A, Nishio M, Guo L, Ikegawa S, Sakurai S, Kihara S, Maurissen TL, Nakamura M, Matsumoto T, Yoshitomi H, Ikeya M, Kawakami N, Yamamoto T, Woltjen K, Ebisuya M, Toguchida J, Alev C. Matsuda M, et al. Among authors: woltjen k. Nature. 2020 Apr;580(7801):124-129. doi: 10.1038/s41586-020-2144-9. Epub 2020 Apr 1. Nature. 2020. PMID: 32238941
Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Gao J, Makiyama T, Yamamoto Y, Kobayashi T, Aoki H, Maurissen TL, Wuriyanghai Y, Kashiwa A, Imamura T, Aizawa T, Huang H, Kohjitani H, Nishikawa M, Chonabayashi K, Fukuyama M, Manabe H, Nakau K, Wada T, Kato K, Toyoda F, Yoshida Y, Makita N, Woltjen K, Ohno S, Kurebayashi N, Murayama T, Sakurai T, Horie M, Kimura T. Gao J, et al. Among authors: woltjen k. Circ Arrhythm Electrophysiol. 2023 Mar;16(3):e011387. doi: 10.1161/CIRCEP.122.011387. Epub 2023 Mar 3. Circ Arrhythm Electrophysiol. 2023. PMID: 36866681
Microhomology-assisted scarless genome editing in human iPSCs.
Kim SI, Matsumoto T, Kagawa H, Nakamura M, Hirohata R, Ueno A, Ohishi M, Sakuma T, Soga T, Yamamoto T, Woltjen K. Kim SI, et al. Among authors: woltjen k. Nat Commun. 2018 Mar 5;9(1):939. doi: 10.1038/s41467-018-03044-y. Nat Commun. 2018. PMID: 29507284 Free PMC article.
72 results