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An automated high inoculation density fed-batch bioreactor, enabled through N-1 perfusion, accommodates clonal diversity and doubles titers.
Biotechnol Prog. 2024 Mar-Apr;40(2):e3410. doi: 10.1002/btpr.3410. Epub 2023 Nov 28.
Biotechnol Prog. 2024.
PMID: 38013663
Automated Raman feed-back control of multiple supplemental feeds to enable an intensified high inoculation density fed-batch platform process.
Webster TA, Hadley BC, Dickson M, Hodgkins J, Olin M, Wolnick N, Armstrong J, Mason C, Downey B.
Webster TA, et al. Among authors: wolnick n.
Bioprocess Biosyst Eng. 2023 Oct;46(10):1457-1470. doi: 10.1007/s00449-023-02912-2. Epub 2023 Aug 26.
Bioprocess Biosyst Eng. 2023.
PMID: 37633861
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Impact of fed-batch process intensification on the productivity and product quality of two CHO cell lines expressing unique novel molecular format proteins.
Wolnick NQ, Dickson MR, Webster TA, Connolly RP, Fernandes N, Encheva V, Crittenden H, Hodgkins J, Hadley BC, Palermo G, Hendrick SJ, Newell RA, Gray G, Siltanen C, Armstrong J, Downey BJ, Mason C.
Wolnick NQ, et al.
Bioprocess Biosyst Eng. 2024 Apr 23. doi: 10.1007/s00449-024-02997-3. Online ahead of print.
Bioprocess Biosyst Eng. 2024.
PMID: 38653840
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