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Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine.
Weber P, Thonhofer M, Averill S, Davies GJ, Santana AG, Müller P, Nasseri SA, Offen WA, Pabst BM, Paschke E, Schalli M, Torvisco A, Tschernutter M, Tysoe C, Windischhofer W, Withers SG, Wolfsgruber A, Wrodnigg TM, Stütz AE. Weber P, et al. Among authors: wolfsgruber a. Molecules. 2020 Sep 3;25(17):4025. doi: 10.3390/molecules25174025. Molecules. 2020. PMID: 32899288 Free PMC article.
C-5a-substituted validamine type glycosidase inhibitors.
Schalli M, Wolfsgruber A, Gonzalez Santana A, Tysoe C, Fischer R, Stütz AE, Thonhofer M, Withers SG. Schalli M, et al. Among authors: wolfsgruber a. Carbohydr Res. 2017 Feb 22;440-441:1-9. doi: 10.1016/j.carres.2017.01.006. Epub 2017 Jan 13. Carbohydr Res. 2017. PMID: 28135569
New α-galactosidase-inhibiting aminohydroxycyclopentanes.
Weber P, Fischer R, Nasseri SA, Stütz AE, Thonhofer M, Withers SG, Wolfsgruber A, Wrodnigg TM. Weber P, et al. Among authors: wolfsgruber a. RSC Adv. 2021 Apr 29;11(26):15943-15951. doi: 10.1039/d1ra02507d. eCollection 2021 Apr 26. RSC Adv. 2021. PMID: 35481199 Free PMC article.
Highly functionalized diaminocyclopentanes: A new route to potent and selective inhibitors of human O-GlcNAcase.
Weber P, Mészáros Z, Bojarová P, Ebner M, Fischer R, Křen V, Kulik N, Müller P, Vlachová M, Slámová K, Stütz AE, Thonhofer M, Torvisco A, Wrodnigg TM, Wolfsgruber A. Weber P, et al. Among authors: wolfsgruber a. Bioorg Chem. 2023 Nov;140:106819. doi: 10.1016/j.bioorg.2023.106819. Epub 2023 Aug 28. Bioorg Chem. 2023. PMID: 37666109 Free article.
Ligand-Directed Chemistry on Glycoside Hydrolases - A Proof of Concept Study.
Prasch H, Wolfsgruber A, Thonhofer M, Culum A, Mandl C, Weber P, Zündel M, Nasseri SA, Gonzalez Santana A, Tegl G, Nidetzky B, Gruber K, Stütz AE, Withers SG, Wrodnigg TM. Prasch H, et al. Among authors: wolfsgruber a. Chembiochem. 2023 Dec 1;24(23):e202300480. doi: 10.1002/cbic.202300480. Epub 2023 Oct 10. Chembiochem. 2023. PMID: 37715738