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Proteomic changes in the human cerebrovasculature in Alzheimer's disease and related tauopathies linked to peripheral biomarkers in plasma and cerebrospinal fluid.
Wojtas AM, Dammer EB, Guo Q, Ping L, Shantaraman A, Duong DM, Yin L, Fox EJ, Seifar F, Lee EB, Johnson ECB, Lah JJ, Levey AI, Levites Y, Rangaraju S, Golde TE, Seyfried NT. Wojtas AM, et al. Alzheimers Dement. 2024 May 7. doi: 10.1002/alz.13821. Online ahead of print. Alzheimers Dement. 2024. PMID: 38713744
Proteomic Changes in the Human Cerebrovasculature in Alzheimer's Disease and Related Tauopathies Linked to Peripheral Biomarkers in Plasma and Cerebrospinal Fluid.
Wojtas AM, Dammer EB, Guo Q, Ping L, Shantaraman A, Duong DM, Yin L, Fox EJ, Seifar F, Lee EB, Johnson ECB, Lah JJ, Levey AI, Levites Y, Rangaraju S, Golde TE, Seyfried NT. Wojtas AM, et al. medRxiv [Preprint]. 2024 Jan 11:2024.01.10.24301099. doi: 10.1101/2024.01.10.24301099. medRxiv. 2024. PMID: 38260316 Free PMC article. Preprint.
Widespread choroid plexus contamination in sampling and profiling of brain tissue.
Olney KC, Todd KT, Pallegar PN, Jensen TD, Cadiz MP, Gibson KA, Barnett JH, de Ávila C, Bouchal SM, Rabichow BE, Ding Z, Wojtas AM, Wilson MA, Fryer JD. Olney KC, et al. Among authors: wojtas am. Mol Psychiatry. 2022 Mar;27(3):1839-1847. doi: 10.1038/s41380-021-01416-3. Epub 2022 Jan 5. Mol Psychiatry. 2022. PMID: 34983929 Free PMC article.
Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation.
Wojtas AM, Carlomagno Y, Sens JP, Kang SS, Jensen TD, Kurti A, Baker KE, Berry TJ, Phillips VR, Castanedes MC, Awan A, DeTure M, De Castro CHF, Librero AL, Yue M, Daughrity L, Jansen-West KR, Cook CN, Dickson DW, Petrucelli L, Fryer JD. Wojtas AM, et al. Acta Neuropathol Commun. 2020 Dec 1;8(1):210. doi: 10.1186/s40478-020-01079-1. Acta Neuropathol Commun. 2020. PMID: 33261653 Free PMC article.
Astrocyte-derived clusterin suppresses amyloid formation in vivo.
Wojtas AM, Sens JP, Kang SS, Baker KE, Berry TJ, Kurti A, Daughrity L, Jansen-West KR, Dickson DW, Petrucelli L, Bu G, Liu CC, Fryer JD. Wojtas AM, et al. Mol Neurodegener. 2020 Nov 27;15(1):71. doi: 10.1186/s13024-020-00416-1. Mol Neurodegener. 2020. PMID: 33246484 Free PMC article.
Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways.
Wojtas AM, Kang SS, Olley BM, Gatherer M, Shinohara M, Lozano PA, Liu CC, Kurti A, Baker KE, Dickson DW, Yue M, Petrucelli L, Bu G, Carare RO, Fryer JD. Wojtas AM, et al. Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6962-E6971. doi: 10.1073/pnas.1701137114. Epub 2017 Jul 12. Proc Natl Acad Sci U S A. 2017. PMID: 28701379 Free PMC article.
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.
Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP. Kim HJ, et al. Among authors: wojtas am. Nature. 2013 Mar 28;495(7442):467-73. doi: 10.1038/nature11922. Epub 2013 Mar 3. Nature. 2013. PMID: 23455423 Free PMC article.