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Page 1
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice.
Deprez-Poulain R, Hennuyer N, Bosc D, Liang WG, Enée E, Marechal X, Charton J, Totobenazara J, Berte G, Jahklal J, Verdelet T, Dumont J, Dassonneville S, Woitrain E, Gauriot M, Paquet C, Duplan I, Hermant P, Cantrelle FX, Sevin E, Culot M, Landry V, Herledan A, Piveteau C, Lippens G, Leroux F, Tang WJ, van Endert P, Staels B, Deprez B. Deprez-Poulain R, et al. Among authors: woitrain e. Nat Commun. 2015 Sep 23;6:8250. doi: 10.1038/ncomms9250. Nat Commun. 2015. PMID: 26394692 Free PMC article.
The novel selective PPARα modulator (SPPARMα) pemafibrate improves dyslipidemia, enhances reverse cholesterol transport and decreases inflammation and atherosclerosis.
Hennuyer N, Duplan I, Paquet C, Vanhoutte J, Woitrain E, Touche V, Colin S, Vallez E, Lestavel S, Lefebvre P, Staels B. Hennuyer N, et al. Among authors: woitrain e. Atherosclerosis. 2016 Jun;249:200-8. doi: 10.1016/j.atherosclerosis.2016.03.003. Epub 2016 Mar 4. Atherosclerosis. 2016. PMID: 27108950
Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis.
Bobowski-Gerard M, Boulet C, Zummo FP, Dubois-Chevalier J, Gheeraert C, Bou Saleh M, Strub JM, Farce A, Ploton M, Guille L, Vandel J, Bongiovanni A, Very N, Woitrain E, Deprince A, Lalloyer F, Bauge E, Ferri L, Ntandja-Wandji LC, Cotte AK, Grangette C, Vallez E, Cianférani S, Raverdy V, Caiazzo R, Gnemmi V, Leteurtre E, Pourcet B, Paumelle R, Ravnskjaer K, Lassailly G, Haas JT, Mathurin P, Pattou F, Dubuquoy L, Staels B, Lefebvre P, Eeckhoute J. Bobowski-Gerard M, et al. Among authors: woitrain e. Nat Commun. 2022 Sep 10;13(1):5324. doi: 10.1038/s41467-022-33063-9. Nat Commun. 2022. PMID: 36088459 Free PMC article.
Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin.
Lefebvre P, Lalloyer F, Baugé E, Pawlak M, Gheeraert C, Dehondt H, Vanhoutte J, Woitrain E, Hennuyer N, Mazuy C, Bobowski-Gérard M, Zummo FP, Derudas B, Driessen A, Hubens G, Vonghia L, Kwanten WJ, Michielsen P, Vanwolleghem T, Eeckhoute J, Verrijken A, Van Gaal L, Francque S, Staels B. Lefebvre P, et al. Among authors: woitrain e. JCI Insight. 2017 Jul 6;2(13):e92264. doi: 10.1172/jci.insight.92264. eCollection 2017 Jul 6. JCI Insight. 2017. PMID: 28679947 Free PMC article.
Transcriptional Network Analysis Implicates Altered Hepatic Immune Function in NASH development and resolution.
Haas JT, Vonghia L, Mogilenko DA, Verrijken A, Molendi-Coste O, Fleury S, Deprince A, Nikitin A, Woitrain E, Ducrocq-Geoffroy L, Pic S, Derudas B, Dehondt H, Gheeraert C, Van Gaal L, Driessen A, Lefebvre P, Staels B, Francque S, Dombrowicz D. Haas JT, et al. Among authors: woitrain e. Nat Metab. 2019 Jun;1(6):604-614. doi: 10.1038/s42255-019-0076-1. Epub 2019 Jun 14. Nat Metab. 2019. PMID: 31701087 Free PMC article.
Author Correction: Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution.
Haas JT, Vonghia L, Mogilenko DA, Verrijken A, Molendi-Coste O, Fleury S, Deprince A, Nikitin A, Woitrain E, Ducrocq-Geoffroy L, Pic S, Derudas B, Dehondt H, Gheeraert C, Van Gaal L, Driessen A, Lefebvre P, Staels B, Francque S, Dombrowicz D. Haas JT, et al. Among authors: woitrain e. Nat Metab. 2019 Jul;1(7):744. doi: 10.1038/s42255-019-0093-0. Nat Metab. 2019. PMID: 32694642
Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride-rich lipoprotein metabolism.
Deprince A, Hennuyer N, Kooijman S, Pronk ACM, Baugé E, Lienard V, Verrijken A, Dirinck E, Vonghia L, Woitrain E, Kloosterhuis NJ, Marez E, Jacquemain P, Wolters JC, Lalloyer F, Eberlé D, Quemener S, Vallez E, Tailleux A, Kouach M, Goossens JF, Raverdy V, Derudas B, Kuivenhoven JA, Croyal M, van de Sluis B, Francque S, Pattou F, Rensen PCN, Staels B, Haas JT. Deprince A, et al. Among authors: woitrain e. Hepatology. 2023 Apr 1;77(4):1287-1302. doi: 10.1002/hep.32631. Epub 2022 Jul 15. Hepatology. 2023. PMID: 35735979 Free PMC article.
The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ.
Firmin FF, Oger F, Gheeraert C, Dubois-Chevalier J, Vercoutter-Edouart AS, Alzaid F, Mazuy C, Dehondt H, Alexandre J, Derudas B, Dhalluin Q, Ploton M, Berthier A, Woitrain E, Lefebvre T, Venteclef N, Pattou F, Staels B, Eeckhoute J, Lefebvre P. Firmin FF, et al. Among authors: woitrain e. Sci Rep. 2017 Oct 26;7(1):14087. doi: 10.1038/s41598-017-14570-y. Sci Rep. 2017. PMID: 29075020 Free PMC article. Clinical Trial.
Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver.
Dubois V, Gheeraert C, Vankrunkelsven W, Dubois-Chevalier J, Dehondt H, Bobowski-Gerard M, Vinod M, Zummo FP, Güiza F, Ploton M, Dorchies E, Pineau L, Boulinguiez A, Vallez E, Woitrain E, Baugé E, Lalloyer F, Duhem C, Rabhi N, van Kesteren RE, Chiang CM, Lancel S, Duez H, Annicotte JS, Paumelle R, Vanhorebeek I, Van den Berghe G, Staels B, Lefebvre P, Eeckhoute J. Dubois V, et al. Among authors: woitrain e. Mol Syst Biol. 2020 May;16(5):e9156. doi: 10.15252/msb.20199156. Mol Syst Biol. 2020. PMID: 32407006 Free PMC article.
High liver fibrosis scores in metabolic dysfunction-associated fatty liver disease patients are associated with adverse atrial remodeling and atrial fibrillation recurrence following catheter ablation.
Decoin R, Butruille L, Defrancq T, Robert J, Destrait N, Coisne A, Aghezzaf S, Woitrain E, Gouda Z, Schino S, Klein C, Maboudou P, Brigadeau F, Klug D, Vincentelli A, Dombrowicz D, Staels B, Montaigne D, Ninni S. Decoin R, et al. Among authors: woitrain e. Front Endocrinol (Lausanne). 2022 Aug 31;13:957245. doi: 10.3389/fendo.2022.957245. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36120456 Free PMC article.
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