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Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors.
Cheng Y, Li G, Smedley CJ, Giel MC, Kitamura S, Woehl JL, Bianco G, Forli S, Homer JA, Cappiello JR, Wolan DW, Moses JE, Sharpless KB. Cheng Y, et al. Among authors: woehl jl. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37):e2208540119. doi: 10.1073/pnas.2208540119. Epub 2022 Sep 7. Proc Natl Acad Sci U S A. 2022. PMID: 36070343 Free PMC article.
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.
Zheng Q, Woehl JL, Kitamura S, Santos-Martins D, Smedley CJ, Li G, Forli S, Moses JE, Wolan DW, Sharpless KB. Zheng Q, et al. Among authors: woehl jl. Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):18808-18814. doi: 10.1073/pnas.1909972116. Epub 2019 Sep 4. Proc Natl Acad Sci U S A. 2019. PMID: 31484779 Free PMC article.
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry.
Kitamura S, Zheng Q, Woehl JL, Solania A, Chen E, Dillon N, Hull MV, Kotaniguchi M, Cappiello JR, Kitamura S, Nizet V, Sharpless KB, Wolan DW. Kitamura S, et al. Among authors: woehl jl. J Am Chem Soc. 2020 Jun 24;142(25):10899-10904. doi: 10.1021/jacs.9b13652. Epub 2020 Jun 10. J Am Chem Soc. 2020. PMID: 32479075 Free PMC article.
Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.
Misson Mindrebo L, Liu H, Ozorowski G, Tran Q, Woehl J, Khalek I, Smith JM, Barman S, Zhao F, Keating C, Limbo O, Verma M, Liu J, Stanfield RL, Zhu X, Turner HL, Sok D, Huang PS, Burton DR, Ward AB, Wilson IA, Jardine JG. Misson Mindrebo L, et al. Proc Natl Acad Sci U S A. 2023 Jun 13;120(24):e2216612120. doi: 10.1073/pnas.2216612120. Epub 2023 Jun 5. Proc Natl Acad Sci U S A. 2023. PMID: 37276407 Free PMC article.
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model.
Rogers TF, Zhao F, Huang D, Beutler N, Burns A, He WT, Limbo O, Smith C, Song G, Woehl J, Yang L, Abbott RK, Callaghan S, Garcia E, Hurtado J, Parren M, Peng L, Ramirez S, Ricketts J, Ricciardi MJ, Rawlings SA, Wu NC, Yuan M, Smith DM, Nemazee D, Teijaro JR, Voss JE, Wilson IA, Andrabi R, Briney B, Landais E, Sok D, Jardine JG, Burton DR. Rogers TF, et al. Science. 2020 Aug 21;369(6506):956-963. doi: 10.1126/science.abc7520. Epub 2020 Jun 15. Science. 2020. PMID: 32540903 Free PMC article.
Sialic Acid Ligands of CD28 Suppress Costimulation of T Cells.
Edgar LJ, Thompson AJ, Vartabedian VF, Kikuchi C, Woehl JL, Teijaro JR, Paulson JC. Edgar LJ, et al. Among authors: woehl jl. ACS Cent Sci. 2021 Sep 22;7(9):1508-1515. doi: 10.1021/acscentsci.1c00525. Epub 2021 Aug 23. ACS Cent Sci. 2021. PMID: 34584952 Free PMC article.
Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways.
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG. Zhao F, et al. iScience. 2022 Sep 16;25(9):104914. doi: 10.1016/j.isci.2022.104914. Epub 2022 Aug 11. iScience. 2022. PMID: 35971553 Free PMC article.
17 results