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PI3K: A master regulator of brain metastasis-promoting macrophages/microglia.
Blazquez R, Wlochowitz D, Wolff A, Seitz S, Wachter A, Perera-Bel J, Bleckmann A, Beißbarth T, Salinas G, Riemenschneider MJ, Proescholdt M, Evert M, Utpatel K, Siam L, Schatlo B, Balkenhol M, Stadelmann C, Schildhaus HU, Korf U, Reinz E, Wiemann S, Vollmer E, Schulz M, Ritter U, Hanisch UK, Pukrop T. Blazquez R, et al. Among authors: wlochowitz d. Glia. 2018 Nov;66(11):2438-2455. doi: 10.1002/glia.23485. Epub 2018 Oct 25. Glia. 2018. PMID: 30357946
LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer.
Blazquez R, Rietkötter E, Wenske B, Wlochowitz D, Sparrer D, Vollmer E, Müller G, Seegerer J, Sun X, Dettmer K, Barrantes-Freer A, Stange L, Utpatel K, Bleckmann A, Treiber H, Bohnenberger H, Lenz C, Schulz M, Reimelt C, Hackl C, Grade M, Büyüktas D, Siam L, Balkenhol M, Stadelmann C, Kube D, Krahn MP, Proescholdt MA, Riemenschneider MJ, Evert M, Oefner PJ, Klein CA, Hanisch UK, Binder C, Pukrop T. Blazquez R, et al. Among authors: wlochowitz d. Int J Cancer. 2020 Jun 1;146(11):3170-3183. doi: 10.1002/ijc.32742. Epub 2019 Nov 11. Int J Cancer. 2020. PMID: 31626715 Free article.
WNT11/ROR2 signaling is associated with tumor invasion and poor survival in breast cancer.
Menck K, Heinrichs S, Wlochowitz D, Sitte M, Noeding H, Janshoff A, Treiber H, Ruhwedel T, Schatlo B, von der Brelie C, Wiemann S, Pukrop T, Beißbarth T, Binder C, Bleckmann A. Menck K, et al. Among authors: wlochowitz d. J Exp Clin Cancer Res. 2021 Dec 15;40(1):395. doi: 10.1186/s13046-021-02187-z. J Exp Clin Cancer Res. 2021. PMID: 34911552 Free PMC article.
High-Throughput Profiling of Colorectal Cancer Liver Metastases Reveals Intra- and Inter-Patient Heterogeneity in the EGFR and WNT Pathways Associated with Clinical Outcome.
Menck K, Wlochowitz D, Wachter A, Conradi LC, Wolff A, Scheel AH, Korf U, Wiemann S, Schildhaus HU, Bohnenberger H, Wingender E, Pukrop T, Homayounfar K, Beißbarth T, Bleckmann A. Menck K, et al. Among authors: wlochowitz d. Cancers (Basel). 2022 Apr 21;14(9):2084. doi: 10.3390/cancers14092084. Cancers (Basel). 2022. PMID: 35565214 Free PMC article.
Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain.
Blazquez R, Chuang HN, Wenske B, Trigueros L, Wlochowitz D, Liguori R, Ferrazzi F, Regen T, Proescholdt MA, Rohde V, Riemenschneider MJ, Stadelmann C, Bleckmann A, Beißbarth T, van Rossum D, Hanisch UK, Pukrop T. Blazquez R, et al. Among authors: wlochowitz d. Oncogene. 2022 Nov;41(46):5008-5019. doi: 10.1038/s41388-022-02496-3. Epub 2022 Oct 12. Oncogene. 2022. PMID: 36224342 Free PMC article.
Metabolomic Profiling of Blood-Derived Microvesicles in Breast Cancer Patients.
Buentzel J, Klemp HG, Kraetzner R, Schulz M, Dihazi GH, Streit F, Bleckmann A, Menck K, Wlochowitz D, Binder C. Buentzel J, et al. Among authors: wlochowitz d. Int J Mol Sci. 2021 Dec 17;22(24):13540. doi: 10.3390/ijms222413540. Int J Mol Sci. 2021. PMID: 34948336 Free PMC article.