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A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Wei SC, Meijers WC, Axelrod ML, Anang NAS, Screever EM, Wescott EC, Johnson DB, Whitley E, Lehmann L, Courand PY, Mancuso JJ, Himmel LE, Lebrun-Vignes B, Wleklinski MJ, Knollmann BC, Srinivasan J, Li Y, Atolagbe OT, Rao X, Zhao Y, Wang J, Ehrlich LIR, Sharma P, Salem JE, Balko JM, Moslehi JJ, Allison JP. Wei SC, et al. Among authors: wleklinski mj. Cancer Discov. 2021 Mar;11(3):614-625. doi: 10.1158/2159-8290.CD-20-0856. Epub 2020 Nov 30. Cancer Discov. 2021. PMID: 33257470 Free PMC article.
The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT.
Blackwell DJ, Faggioni M, Wleklinski MJ, Gomez-Hurtado N, Venkataraman R, Gibbs CE, Baudenbacher FJ, Gong S, Fishman GI, Boyle PM, Pfeifer K, Knollmann BC. Blackwell DJ, et al. Among authors: wleklinski mj. JCI Insight. 2022 Feb 8;7(3):e151893. doi: 10.1172/jci.insight.151893. JCI Insight. 2022. PMID: 34990403 Free PMC article.
Reprogramming cell fate with a genome-scale library of artificial transcription factors.
Eguchi A, Wleklinski MJ, Spurgat MC, Heiderscheit EA, Kropornicka AS, Vu CK, Bhimsaria D, Swanson SA, Stewart R, Ramanathan P, Kamp TJ, Slukvin I, Thomson JA, Dutton JR, Ansari AZ. Eguchi A, et al. Among authors: wleklinski mj. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8257-E8266. doi: 10.1073/pnas.1611142114. Epub 2016 Dec 5. Proc Natl Acad Sci U S A. 2016. PMID: 27930301 Free PMC article.