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Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa.
Nat Commun. 2022 Dec 1;13(1):7402. doi: 10.1038/s41467-022-35030-w.
Nat Commun. 2022.
PMID: 36456567
Free PMC article.
Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds.
Zender M, Witzgall F, Drees SL, Weidel E, Maurer CK, Fetzner S, Blankenfeldt W, Empting M, Hartmann RW.
Zender M, et al. Among authors: witzgall f.
ACS Chem Biol. 2016 Jun 17;11(6):1755-63. doi: 10.1021/acschembio.6b00156. Epub 2016 Apr 28.
ACS Chem Biol. 2016.
PMID: 27082157
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Structures of the N-Terminal Domain of PqsA in Complex with Anthraniloyl- and 6-Fluoroanthraniloyl-AMP: Substrate Activation in Pseudomonas Quinolone Signal (PQS) Biosynthesis.
Witzgall F, Ewert W, Blankenfeldt W.
Witzgall F, et al.
Chembiochem. 2017 Oct 18;18(20):2045-2055. doi: 10.1002/cbic.201700374. Epub 2017 Sep 18.
Chembiochem. 2017.
PMID: 28834007
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Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence.
Zender M, Witzgall F, Kiefer A, Kirsch B, Maurer CK, Kany AM, Xu N, Schmelz S, Börger C, Blankenfeldt W, Empting M.
Zender M, et al. Among authors: witzgall f.
ChemMedChem. 2020 Jan 17;15(2):188-194. doi: 10.1002/cmdc.201900621. Epub 2019 Nov 28.
ChemMedChem. 2020.
PMID: 31709767
Free PMC article.
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The Alkylquinolone Repertoire of Pseudomonas aeruginosa is Linked to Structural Flexibility of the FabH-like 2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) Biosynthesis Enzyme PqsBC.
Witzgall F, Depke T, Hoffmann M, Empting M, Brönstrup M, Müller R, Blankenfeldt W.
Witzgall F, et al.
Chembiochem. 2018 Jul 16;19(14):1531-1544. doi: 10.1002/cbic.201800153. Epub 2018 Jun 22.
Chembiochem. 2018.
PMID: 29722462
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