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Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.
Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M. Herzner AM, et al. Among authors: wittmann s. Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7. Nat Immunol. 2015. PMID: 26343537 Free PMC article.
Phosphorylation of murine SAMHD1 regulates its antiretroviral activity.
Wittmann S, Behrendt R, Eissmann K, Volkmann B, Thomas D, Ebert T, Cribier A, Benkirane M, Hornung V, Bouzas NF, Gramberg T. Wittmann S, et al. Retrovirology. 2015 Dec 15;12:103. doi: 10.1186/s12977-015-0229-6. Retrovirology. 2015. PMID: 26667483 Free PMC article.
TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner.
Kahle T, Volkmann B, Eissmann K, Herrmann A, Schmitt S, Wittmann S, Merkel L, Reuter N, Stamminger T, Gramberg T. Kahle T, et al. Among authors: wittmann s. Viruses. 2015 Dec 23;8(1):2. doi: 10.3390/v8010002. Viruses. 2015. PMID: 26703718 Free PMC article.
IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation.
Hotter D, Bosso M, Jønsson KL, Krapp C, Stürzel CM, Das A, Littwitz-Salomon E, Berkhout B, Russ A, Wittmann S, Gramberg T, Zheng Y, Martins LJ, Planelles V, Jakobsen MR, Hahn BH, Dittmer U, Sauter D, Kirchhoff F. Hotter D, et al. Among authors: wittmann s. Cell Host Microbe. 2019 Jun 12;25(6):858-872.e13. doi: 10.1016/j.chom.2019.05.002. Epub 2019 Jun 4. Cell Host Microbe. 2019. PMID: 31175045 Free PMC article.
A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1.
Deutschmann J, Schneider A, Gruska I, Vetter B, Thomas D, Kießling M, Wittmann S, Herrmann A, Schindler M, Milbradt J, Ferreirós N, Winkler TH, Wiebusch L, Gramberg T. Deutschmann J, et al. Among authors: wittmann s. Nat Microbiol. 2019 Dec;4(12):2273-2284. doi: 10.1038/s41564-019-0529-z. Epub 2019 Sep 23. Nat Microbiol. 2019. PMID: 31548683
Human TRIM5α senses and restricts LINE-1 elements.
Volkmann B, Wittmann S, Lagisquet J, Deutschmann J, Eissmann K, Ross JJ, Biesinger B, Gramberg T. Volkmann B, et al. Among authors: wittmann s. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17965-17976. doi: 10.1073/pnas.1922366117. Epub 2020 Jul 10. Proc Natl Acad Sci U S A. 2020. PMID: 32651277 Free PMC article.
Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells.
Bosso M, Prelli Bozzo C, Hotter D, Volcic M, Stürzel CM, Rammelt A, Ni Y, Urban S, Becker M, Schelhaas M, Wittmann S, Christensen MH, Schmidt FI, Gramberg T, Sparrer KMJ, Sauter D, Kirchhoff F. Bosso M, et al. Among authors: wittmann s. PLoS Pathog. 2020 Aug 6;16(8):e1008752. doi: 10.1371/journal.ppat.1008752. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32760121 Free PMC article.
145 results