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Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.
Marchetti F, Cardoso R, Chen CL, Douglas GR, Elloway J, Escobar PA, Harper T Jr, Heflich RH, Kidd D, Lynch AM, Myers MB, Parsons BL, Salk JJ, Settivari RS, Smith-Roe SL, Witt KL, Yauk CL, Young R, Zhang S, Minocherhomji S. Marchetti F, et al. Among authors: witt kl. Mutat Res Rev Mutat Res. 2023 Jul-Dec;792:108466. doi: 10.1016/j.mrrev.2023.108466. Epub 2023 Aug 27. Mutat Res Rev Mutat Res. 2023. PMID: 37643677 Free article. Review.
Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing.
Marchetti F, Cardoso R, Chen CL, Douglas GR, Elloway J, Escobar PA, Harper T Jr, Heflich RH, Kidd D, Lynch AM, Myers MB, Parsons BL, Salk JJ, Settivari RS, Smith-Roe SL, Witt KL, Yauk C, Young RR, Zhang S, Minocherhomji S. Marchetti F, et al. Among authors: witt kl. Nat Rev Drug Discov. 2023 Mar;22(3):165-166. doi: 10.1038/d41573-023-00014-y. Nat Rev Drug Discov. 2023. PMID: 36646809 No abstract available.
Evaluation of the herbicide glyphosate, (aminomethyl)phosphonic acid, and glyphosate-based formulations for genotoxic activity using in vitro assays.
Smith-Roe SL, Swartz CD, Rashid A, Christy NC, Sly JE, Chang X, Sipes NS, Shockley KR, Harris SF, McBride SJ, Larson GJ, Collins BJ, Mutlu E, Witt KL. Smith-Roe SL, et al. Among authors: witt kl. Environ Mol Mutagen. 2023 Apr;64(4):202-233. doi: 10.1002/em.22534. Epub 2023 Mar 7. Environ Mol Mutagen. 2023. PMID: 36880770 Free PMC article.
Error-corrected duplex sequencing enables direct detection and quantification of mutations in human TK6 cells with strong inter-laboratory consistency.
Cho E, Swartz CD, Williams A, V Rivas M, Recio L, Witt KL, Schmidt EK, Yaplee J, Smith TH, Van P, Lo FY, Valentine CC 3rd, Salk JJ, Marchetti F, Smith-Roe SL, Yauk CL. Cho E, et al. Among authors: witt kl. Mutat Res Genet Toxicol Environ Mutagen. 2023 Jul;889:503649. doi: 10.1016/j.mrgentox.2023.503649. Epub 2023 May 20. Mutat Res Genet Toxicol Environ Mutagen. 2023. PMID: 37491114 Free article.
Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.
Smith-Roe SL, Hobbs CA, Hull V, Todd Auman J, Recio L, Streicker MA, Rivas MV, Pratt GA, Lo FY, Higgins JE, Schmidt EK, Williams LN, Nachmanson D, Valentine Iii CC, Salk JJ, Witt KL. Smith-Roe SL, et al. Among authors: witt kl. Mutat Res Genet Toxicol Environ Mutagen. 2023 Oct;891:503669. doi: 10.1016/j.mrgentox.2023.503669. Epub 2023 Aug 3. Mutat Res Genet Toxicol Environ Mutagen. 2023. PMID: 37770135 Free article.
171 results