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The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution.
Ballhausen A, Przybilla MJ, Jendrusch M, Haupt S, Pfaffendorf E, Seidler F, Witt J, Hernandez Sanchez A, Urban K, Draxlbauer M, Krausert S, Ahadova A, Kalteis MS, Pfuderer PL, Heid D, Stichel D, Gebert J, Bonsack M, Schott S, Bläker H, Seppälä T, Mecklin JP, Ten Broeke S, Nielsen M, Heuveline V, Krzykalla J, Benner A, Riemer AB, von Knebel Doeberitz M, Kloor M. Ballhausen A, et al. Among authors: witt j. Nat Commun. 2020 Sep 21;11(1):4740. doi: 10.1038/s41467-020-18514-5. Nat Commun. 2020. PMID: 32958755 Free PMC article.
Beta-2-microglobulin Mutations Are Linked to a Distinct Metastatic Pattern and a Favorable Outcome in Microsatellite-Unstable Stage IV Gastrointestinal Cancers.
Busch E, Ahadova A, Kosmalla K, Bohaumilitzky L, Pfuderer PL, Ballhausen A, Witt J, Wittemann JN, Bläker H, Holinski-Feder E, Jäger D, von Knebel Doeberitz M, Haag GM, Kloor M. Busch E, et al. Among authors: witt j. Front Oncol. 2021 Jun 8;11:669774. doi: 10.3389/fonc.2021.669774. eCollection 2021. Front Oncol. 2021. PMID: 34168989 Free PMC article.
Distinct Mutational Profile of Lynch Syndrome Colorectal Cancers Diagnosed under Regular Colonoscopy Surveillance.
Ahadova A, Pfuderer PL, Ahtiainen M, Ballhausen A, Bohaumilitzky L, Kösegi S, Müller N, Tang YL, Kosmalla K, Witt J, Endris V, Stenzinger A, von Knebel Doeberitz M, Bläker H, Renkonen-Sinisalo L, Lepistö A, Böhm J, Mecklin JP, Seppälä TT, Kloor M. Ahadova A, et al. Among authors: witt j. J Clin Med. 2021 Jun 1;10(11):2458. doi: 10.3390/jcm10112458. J Clin Med. 2021. PMID: 34206061 Free PMC article.
Is HLA type a possible cancer risk modifier in Lynch syndrome?
Ahadova A, Witt J, Haupt S, Gallon R, Hüneburg R, Nattermann J, Ten Broeke S, Bohaumilitzky L, Hernandez-Sanchez A, Santibanez-Koref M, Jackson MS, Ahtiainen M, Pylvänäinen K, Andini K, Grolmusz VK, Möslein G, Dominguez-Valentin M, Møller P, Fürst D, Sijmons R, Borthwick GM, Burn J, Mecklin JP, Heuveline V, von Knebel Doeberitz M, Seppälä T, Kloor M. Ahadova A, et al. Among authors: witt j. Int J Cancer. 2023 May 15;152(10):2024-2031. doi: 10.1002/ijc.34312. Epub 2022 Oct 14. Int J Cancer. 2023. PMID: 36214792 Free article. Review.
A simple approach for detecting HLA-A*02 alleles in archival formalin-fixed paraffin-embedded tissue samples and an application example for studying cancer immunoediting.
Witt J, Haupt S, Ahadova A, Bohaumilitzky L, Fuchs V, Ballhausen A, Przybilla MJ, Jendrusch M, Seppälä TT, Fürst D, Walle T, Busch E, Haag GM, Hüneburg R, Nattermann J, von Knebel Doeberitz M, Heuveline V, Kloor M. Witt J, et al. HLA. 2023 Jan;101(1):24-33. doi: 10.1111/tan.14846. Epub 2022 Oct 25. HLA. 2023. PMID: 36251018
A workflow to build PBTK models for novel species.
Schneckener S, Preuss TG, Kuepfer L, Witt J. Schneckener S, et al. Among authors: witt j. Arch Toxicol. 2020 Nov;94(11):3847-3860. doi: 10.1007/s00204-020-02922-z. Epub 2020 Oct 9. Arch Toxicol. 2020. PMID: 33033842 Free PMC article.
720 results