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Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells.
Alkharsah KR, Singh VV, Bosco R, Santag S, Grundhoff A, Konrad A, Stürzl M, Wirth D, Dittrich-Breiholz O, Kracht M, Schulz TF. Alkharsah KR, et al. Among authors: wirth d. J Virol. 2011 Oct;85(19):10375-88. doi: 10.1128/JVI.00226-11. Epub 2011 Jul 27. J Virol. 2011. PMID: 21795355 Free PMC article.
An endothelial cell line infected by Kaposi's sarcoma-associated herpes virus (KSHV) allows the investigation of Kaposi's sarcoma and the validation of novel viral inhibitors in vitro and in vivo.
Dubich T, Lieske A, Santag S, Beauclair G, Rückert J, Herrmann J, Gorges J, Büsche G, Kazmaier U, Hauser H, Stadler M, Schulz TF, Wirth D. Dubich T, et al. Among authors: wirth d. J Mol Med (Berl). 2019 Mar;97(3):311-324. doi: 10.1007/s00109-018-01733-1. Epub 2019 Jan 4. J Mol Med (Berl). 2019. PMID: 30610257
Proliferation status defines functional properties of endothelial cells.
Lipps C, Badar M, Butueva M, Dubich T, Singh VV, Rau S, Weber A, Kracht M, Köster M, May T, Schulz TF, Hauser H, Wirth D. Lipps C, et al. Among authors: wirth d. Cell Mol Life Sci. 2017 Apr;74(7):1319-1333. doi: 10.1007/s00018-016-2417-5. Epub 2016 Nov 16. Cell Mol Life Sci. 2017. PMID: 27853834
Type I Interferon Signaling Controls Gammaherpesvirus Latency In Vivo.
Schwerk J, Kemper L, Bussey KA, Lienenklaus S, Weiss S, Čičin-Šain L, Kröger A, Kalinke U, Collins CM, Speck SH, Messerle M, Wirth D, Brinkmann MM, Hauser H, Köster M. Schwerk J, et al. Among authors: wirth d. Pathogens. 2022 Dec 17;11(12):1554. doi: 10.3390/pathogens11121554. Pathogens. 2022. PMID: 36558888 Free PMC article.
512 results