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Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum.
Kümpornsin K, Kochakarn T, Yeo T, Okombo J, Luth MR, Hoshizaki J, Rawat M, Pearson RD, Schindler KA, Mok S, Park H, Uhlemann AC, Jana GP, Maity BC, Laleu B, Chenu E, Duffy J, Moliner Cubel S, Franco V, Gomez-Lorenzo MG, Gamo FJ, Winzeler EA, Fidock DA, Chookajorn T, Lee MCS. Kümpornsin K, et al. Among authors: winzeler ea. Nat Commun. 2023 May 27;14(1):3059. doi: 10.1038/s41467-023-38774-1. Nat Commun. 2023. PMID: 37244916 Free PMC article.
A systematic map of genetic variation in Plasmodium falciparum.
Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR, Le Roch K, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. Kidgell C, et al. Among authors: winzeler ea. PLoS Pathog. 2006 Jun;2(6):e57. doi: 10.1371/journal.ppat.0020057. Epub 2006 Jun 23. PLoS Pathog. 2006. PMID: 16789840 Free PMC article.
Distinct physiological states of Plasmodium falciparum in malaria-infected patients.
Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, Lander ES, Ndiaye D, Wirth D, Winzeler EA, Mesirov JP, Regev A. Daily JP, et al. Among authors: winzeler ea. Nature. 2007 Dec 13;450(7172):1091-5. doi: 10.1038/nature06311. Epub 2007 Nov 28. Nature. 2007. PMID: 18046333
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.
Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, Spooner M, Tuntland T, Zhou Y, Peters EC, Chatterjee A, Schultz PG, Ward GE, Gray N, Harper J, Winzeler EA. Kato N, et al. Among authors: winzeler ea. Nat Chem Biol. 2008 Jun;4(6):347-56. doi: 10.1038/nchembio.87. Epub 2008 May 4. Nat Chem Biol. 2008. PMID: 18454143
Malaria research in the post-genomic era.
Winzeler EA. Winzeler EA. Nature. 2008 Oct 9;455(7214):751-6. doi: 10.1038/nature07361. Nature. 2008. PMID: 18843360 Free PMC article. Review.
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum.
Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA. Dharia NV, et al. Among authors: winzeler ea. Genome Biol. 2009 Feb 13;10(2):R21. doi: 10.1186/gb-2009-10-2-r21. Genome Biol. 2009. PMID: 19216790 Free PMC article.
Spiroindolones, a potent compound class for the treatment of malaria.
Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, Suwanarusk R, Jegla T, Schmitt EK, Beck HP, Brun R, Nosten F, Renia L, Dartois V, Keller TH, Fidock DA, Winzeler EA, Diagana TT. Rottmann M, et al. Among authors: winzeler ea. Science. 2010 Sep 3;329(5996):1175-80. doi: 10.1126/science.1193225. Science. 2010. PMID: 20813948 Free PMC article.
219 results