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The TWEAK receptor Fn14 is a therapeutic target in melanoma: immunotoxins targeting Fn14 receptor for malignant melanoma treatment.
Zhou H, Ekmekcioglu S, Marks JW, Mohamedali KA, Asrani K, Phillips KK, Brown SA, Cheng E, Weiss MB, Hittelman WN, Tran NL, Yagita H, Winkles JA, Rosenblum MG. Zhou H, et al. Among authors: winkles ja. J Invest Dermatol. 2013 Apr;133(4):1052-62. doi: 10.1038/jid.2012.402. Epub 2012 Nov 29. J Invest Dermatol. 2013. PMID: 23190886 Free PMC article.
Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC.
Zhou H, Mohamedali KA, Gonzalez-Angulo AM, Cao Y, Migliorini M, Cheung LH, LoBello J, Lei X, Qi Y, Hittelman WN, Winkles JA, Tran NL, Rosenblum MG. Zhou H, et al. Among authors: winkles ja. Mol Cancer Ther. 2014 Nov;13(11):2688-705. doi: 10.1158/1535-7163.MCT-14-0346. Epub 2014 Sep 19. Mol Cancer Ther. 2014. PMID: 25239934 Free PMC article.
TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration.
Girgenrath M, Weng S, Kostek CA, Browning B, Wang M, Brown SA, Winkles JA, Michaelson JS, Allaire N, Schneider P, Scott ML, Hsu YM, Yagita H, Flavell RA, Miller JB, Burkly LC, Zheng TS. Girgenrath M, et al. Among authors: winkles ja. EMBO J. 2006 Dec 13;25(24):5826-39. doi: 10.1038/sj.emboj.7601441. Epub 2006 Nov 23. EMBO J. 2006. PMID: 17124496 Free PMC article.
The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity.
Willis AL, Tran NL, Chatigny JM, Charlton N, Vu H, Brown SA, Black MA, McDonough WS, Fortin SP, Niska JR, Winkles JA, Cunliffe HE. Willis AL, et al. Among authors: winkles ja. Mol Cancer Res. 2008 May;6(5):725-34. doi: 10.1158/1541-7786.MCR-08-0005. Mol Cancer Res. 2008. PMID: 18505918 Free PMC article.
127 results