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PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma.
Sharma G, Ojha R, Noguera-Ortega E, Rebecca VW, Attanasio J, Liu S, Piao S, Lee JJ, Nicastri MC, Harper SL, Ronghe A, Jain V, Winkler JD, Speicher DW, Mastio J, Gimotty PA, Xu X, Wherry EJ, Gabrilovich DI, Amaravadi RK. Sharma G, et al. Among authors: winkler jd. JCI Insight. 2020 Sep 3;5(17):e133225. doi: 10.1172/jci.insight.133225. JCI Insight. 2020. PMID: 32780726 Free PMC article.
Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma.
DeVorkin L, Hattersley M, Kim P, Ries J, Spowart J, Anglesio MS, Levi SM, Huntsman DG, Amaravadi RK, Winkler JD, Tinker AV, Lum JJ. DeVorkin L, et al. Among authors: winkler jd. Mol Cancer Res. 2017 Mar;15(3):250-258. doi: 10.1158/1541-7786.MCR-16-0132. Epub 2017 Feb 9. Mol Cancer Res. 2017. PMID: 28184014 Free PMC article.
Small molecule inhibitors of integrin alpha2beta1.
Choi S, Vilaire G, Marcinkiewicz C, Winkler JD, Bennett JS, DeGrado WF. Choi S, et al. J Med Chem. 2007 Nov 1;50(22):5457-62. doi: 10.1021/jm070252b. Epub 2007 Oct 4. J Med Chem. 2007. PMID: 17915848 Free PMC article.
Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents.
Vasilevskaya IA, Selvakumaran M, Hierro LC, Goldstein SR, Winkler JD, O'Dwyer PJ. Vasilevskaya IA, et al. Among authors: winkler jd. Clin Cancer Res. 2015 Sep 15;21(18):4143-52. doi: 10.1158/1078-0432.CCR-15-0352. Epub 2015 May 28. Clin Cancer Res. 2015. PMID: 26023085 Free PMC article.
CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers.
Vijayaraghavan S, Karakas C, Doostan I, Chen X, Bui T, Yi M, Raghavendra AS, Zhao Y, Bashour SI, Ibrahim NK, Karuturi M, Wang J, Winkler JD, Amaravadi RK, Hunt KK, Tripathy D, Keyomarsi K. Vijayaraghavan S, et al. Among authors: winkler jd. Nat Commun. 2017 Jun 27;8:15916. doi: 10.1038/ncomms15916. Nat Commun. 2017. PMID: 28653662 Free PMC article.
Lysosomal lipid peroxidation regulates tumor immunity.
Bhardwaj M, Lee JJ, Versace AM, Harper SL, Goldman AR, Crissey MAS, Jain V, Singh MP, Vernon M, Aplin AE, Lee S, Morita M, Winkler JD, Liu Q, Speicher DW, Amaravadi RK. Bhardwaj M, et al. Among authors: winkler jd. J Clin Invest. 2023 Apr 17;133(8):e164596. doi: 10.1172/JCI164596. J Clin Invest. 2023. PMID: 36795483 Free PMC article.
1,546 results