Winkler A - Search Results

1

The Interleukin-1 Receptor-Associated Kinase 4 Inhibitor PF-06650833 Blocks Inflammation in Preclinical Models of Rheumatic Disease and in Humans Enrolled in a Randomized Clinical Trial.

Winkler A, Sun W, De S, Jiao A, Sharif MN, Symanowicz PT, Athale S, Shin JH, Wang J, Jacobson BA, Ramsey SJ, Dower K, Andreyeva T, Liu H, Hegen M, Homer BL, Brodfuehrer J, Tilley M, Gilbert SA, Danto SI, Beebe JJ, Barnes BJ, Pascual V, Lin LL, Kilty I, Fleming M, Rao VR. Winkler A, et al. Arthritis Rheumatol. 2021 Dec;73(12):2206-2218. doi: 10.1002/art.41953. Epub 2021 Nov 1. Arthritis Rheumatol. 2021. PMID: 34423919 Free PMC article. Clinical Trial.

2

IRAK4 kinase activity controls Toll-like receptor-induced inflammation through the transcription factor IRF5 in primary human monocytes.

Cushing L, Winkler A, Jelinsky SA, Lee K, Korver W, Hawtin R, Rao VR, Fleming M, Lin LL. Cushing L, et al. Among authors: winkler a. J Biol Chem. 2017 Nov 10;292(45):18689-18698. doi: 10.1074/jbc.M117.796912. Epub 2017 Sep 18. J Biol Chem. 2017. PMID: 28924041 Free PMC article.

3

B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation.

De S, Zhang B, Shih T, Singh S, Winkler A, Donnelly R, Barnes BJ. De S, et al. Among authors: winkler a. Front Immunol. 2018 Jan 10;8:1938. doi: 10.3389/fimmu.2017.01938. eCollection 2017. Front Immunol. 2018. PMID: 29367853 Free PMC article.

4

Acidic mammalian chitinase is not a critical target for allergic airway disease.

Fitz LJ, DeClercq C, Brooks J, Kuang W, Bates B, Demers D, Winkler A, Nocka K, Jiao A, Greco RM, Mason LE, Fleming M, Quazi A, Wright J, Goldman S, Hubeau C, Williams CM. Fitz LJ, et al. Among authors: winkler a. Am J Respir Cell Mol Biol. 2012 Jan;46(1):71-9. doi: 10.1165/rcmb.2011-0095OC. Am J Respir Cell Mol Biol. 2012. PMID: 21836154

5

Optimized protocols for studying the NLRP3 inflammasome and assessment of potential targets of CP-453,773 in undifferentiated THP1 cells.

Guzova JA, Primiano MJ, Jiao A, Stock J, Lee C, Winkler AR, Hall JP. Guzova JA, et al. Among authors: winkler ar. J Immunol Methods. 2019 Apr;467:19-28. doi: 10.1016/j.jim.2019.02.002. Epub 2019 Feb 5. J Immunol Methods. 2019. PMID: 30735689

6

Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.

Hall JP, Kurdi Y, Hsu S, Cuozzo J, Liu J, Telliez JB, Seidl KJ, Winkler A, Hu Y, Green N, Askew GR, Tam S, Clark JD, Lin LL. Hall JP, et al. Among authors: winkler a. J Biol Chem. 2007 Nov 16;282(46):33295-33304. doi: 10.1074/jbc.M703694200. Epub 2007 Sep 11. J Biol Chem. 2007. PMID: 17848581 Free article.

7

Corrigendum to "Optimized protocols for studying the NLRP3 inflammasome and assessment of potential targets of CP-453,773 in undifferentiated THP1 cells" [Journal of Immunological Methods 467 (2019) 19-28].

Guzova JA, Primiano MJ, Jiao A, Stock J, Lee C, Winkler AR, Hall JP. Guzova JA, et al. Among authors: winkler ar. J Immunol Methods. 2019 May;468:67. doi: 10.1016/j.jim.2019.03.012. J Immunol Methods. 2019. PMID: 30947983 No abstract available.

8

Evolutionary and biochemical differences between human and monkey acidic mammalian chitinases.

Krykbaev R, Fitz LJ, Reddy PS, Winkler A, Xuan D, Yang X, Fleming M, Wolf SF. Krykbaev R, et al. Among authors: winkler a. Gene. 2010 Mar 1;452(2):63-71. doi: 10.1016/j.gene.2009.12.005. Epub 2009 Dec 28. Gene. 2010. PMID: 20036323

9

An inverse relationship between peroxisome proliferator-activated receptor gamma and allergic airway inflammation in an allergen challenge model.

Kobayashi M, Thomassen MJ, Rambasek T, Bonfield TL, Raychaudhuri B, Malur A, Winkler AR, Barna BP, Goldman SJ, Kavuru MS. Kobayashi M, et al. Among authors: winkler ar. Ann Allergy Asthma Immunol. 2005 Nov;95(5):468-73. doi: 10.1016/S1081-1206(10)61173-8. Ann Allergy Asthma Immunol. 2005. PMID: 16312170 Clinical Trial.

10

Single cell sequencing identifies clonally expanded synovial CD4⁺ T_PH cells expressing GPR56 in rheumatoid arthritis.

Argyriou A, Wadsworth MH 2nd, Lendvai A, Christensen SM, Hensvold AH, Gerstner C, van Vollenhoven A, Kravarik K, Winkler A, Malmström V, Chemin K. Argyriou A, et al. Among authors: winkler a. Nat Commun. 2022 Jul 13;13(1):4046. doi: 10.1038/s41467-022-31519-6. Nat Commun. 2022. PMID: 35831277 Free PMC article.

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