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Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
Tsutsumi N, Masoumi Z, James SC, Tucker JA, Winkelmann H, Grey W, Picton LK, Moss L, Wilson SC, Caveney NA, Jude KM, Gati C, Piehler J, Hitchcock IS, Garcia KC. Tsutsumi N, et al. Among authors: winkelmann h. Cell. 2023 Sep 14;186(19):4189-4203.e22. doi: 10.1016/j.cell.2023.07.037. Epub 2023 Aug 25. Cell. 2023. PMID: 37633268 Free article.
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.
Wilmes S, Hafer M, Vuorio J, Tucker JA, Winkelmann H, Löchte S, Stanly TA, Pulgar Prieto KD, Poojari C, Sharma V, Richter CP, Kurre R, Hubbard SR, Garcia KC, Moraga I, Vattulainen I, Hitchcock IS, Piehler J. Wilmes S, et al. Among authors: winkelmann h. Science. 2020 Feb 7;367(6478):643-652. doi: 10.1126/science.aaw3242. Science. 2020. PMID: 32029621 Free PMC article.
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
Glassman CR, Su L, Majri-Morrison SS, Winkelmann H, Mo F, Li P, Pérez-Cruz M, Ho PP, Koliesnik I, Nagy N, Hnizdilova T, Picton LK, Kovar M, Bollyky P, Steinman L, Meyer E, Piehler J, Leonard WJ, Garcia KC. Glassman CR, et al. Among authors: winkelmann h. Elife. 2021 May 18;10:e65777. doi: 10.7554/eLife.65777. Elife. 2021. PMID: 34003116 Free PMC article.
Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.
Richter D, Moraga I, Winkelmann H, Birkholz O, Wilmes S, Schulte M, Kraich M, Kenneweg H, Beutel O, Selenschik P, Paterok D, Gavutis M, Schmidt T, Garcia KC, Müller TD, Piehler J. Richter D, et al. Among authors: winkelmann h. Nat Commun. 2017 Jul 14;8:15976. doi: 10.1038/ncomms15976. Nat Commun. 2017. PMID: 28706306 Free PMC article.
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S. Gaggero S, et al. Among authors: winkelmann h. Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2. Sci Immunol. 2022. PMID: 36459543
[Traumatic and degenerative tendon lesions of the hand].
Schöffl V, Winkelmann HP. Schöffl V, et al. Among authors: winkelmann hp. Orthopade. 2010 Dec;39(12):1108-16. doi: 10.1007/s00132-010-1688-z. Orthopade. 2010. PMID: 21052633 Review. German.
The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure: a prospective, randomized, controlled prevention trial of the German Hypertension League.
Lüders S, Schrader J, Berger J, Unger T, Zidek W, Böhm M, Middeke M, Motz W, Lübcke C, Gansz A, Brokamp L, Schmieder RE, Trenkwalder P, Haller H, Dominiak P; PHARAO Study Group. Lüders S, et al. J Hypertens. 2008 Jul;26(7):1487-96. doi: 10.1097/HJH.0b013e3282ff8864. J Hypertens. 2008. PMID: 18551027 Clinical Trial.
[Therapy of injuries of the pulley system in sport climbers].
Schöffl V, Hochholzer T, Winkelmann HP, Strecker W. Schöffl V, et al. Among authors: winkelmann hp. Handchir Mikrochir Plast Chir. 2004 Aug;36(4):231-6. doi: 10.1055/s-2004-821034. Handchir Mikrochir Plast Chir. 2004. PMID: 15368149 German.
82 results