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Concomitant inhibition of the thioredoxin system and nonhomologous DNA repair potently sensitizes Philadelphia-positive lymphoid leukemia to tyrosine kinase inhibitors.
Komorowski L, Dabkowska A, Madzio J, Pastorczak A, Szczygiel K, Janowska M, Fidyt K, Bielecki M, Hunia J, Bajor M, Stoklosa T, Winiarska M, Patkowska E, Firczuk M. Komorowski L, et al. Among authors: winiarska m. Hemasphere. 2024 Mar 14;8(3):e56. doi: 10.1002/hem3.56. eCollection 2024 Mar. Hemasphere. 2024. PMID: 38486859 Free PMC article.
Efficient chimeric antigen receptor targeting of a central epitope of CD22.
Casey NP, Klee CH, Fåne A, Caulier B, Graczyk-Jarzynka A, Krawczyk M, Fidyt K, Josefsson SE, Köksal H, Dillard P, Patkowska E, Firczuk M, Smeland EB, Winiarska M, Myklebust JH, Inderberg EM, Wälchli S. Casey NP, et al. Among authors: winiarska m. J Biol Chem. 2023 Jul;299(7):104883. doi: 10.1016/j.jbc.2023.104883. Epub 2023 Jun 1. J Biol Chem. 2023. PMID: 37269947 Free PMC article.
Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax.
Fidyt K, Pastorczak A, Cyran J, Crump NT, Goral A, Madzio J, Muchowicz A, Poprzeczko M, Domka K, Komorowski L, Winiarska M, Harman JR, Siudakowska K, Graczyk-Jarzynka A, Patkowska E, Lech-Maranda E, Mlynarski W, Golab J, Milne TA, Firczuk M. Fidyt K, et al. Among authors: winiarska m. Oncogene. 2022 Mar;41(11):1600-1609. doi: 10.1038/s41388-022-02196-y. Epub 2022 Jan 28. Oncogene. 2022. PMID: 35091682 Free PMC article.
PD-L1 CAR effector cells induce self-amplifying cytotoxic effects against target cells.
Bajor M, Graczyk-Jarzynka A, Marhelava K, Burdzinska A, Muchowicz A, Goral A, Zhylko A, Soroczynska K, Retecki K, Krawczyk M, Klopotowska M, Pilch Z, Paczek L, Malmberg KJ, Wälchli S, Winiarska M, Zagozdzon R. Bajor M, et al. Among authors: winiarska m. J Immunother Cancer. 2022 Jan;10(1):e002500. doi: 10.1136/jitc-2021-002500. J Immunother Cancer. 2022. PMID: 35078921 Free PMC article.
PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress.
Klopotowska M, Bajor M, Graczyk-Jarzynka A, Kraft A, Pilch Z, Zhylko A, Firczuk M, Baranowska I, Lazniewski M, Plewczynski D, Goral A, Soroczynska K, Domagala J, Marhelava K, Slusarczyk A, Retecki K, Ramji K, Krawczyk M, Temples MN, Sharma B, Lachota M, Netskar H, Malmberg KJ, Zagozdzon R, Winiarska M. Klopotowska M, et al. Among authors: winiarska m. Cancer Immunol Res. 2022 Feb;10(2):228-244. doi: 10.1158/2326-6066.CIR-20-1023. Epub 2021 Dec 1. Cancer Immunol Res. 2022. PMID: 34853030 Free PMC article.
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