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A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease.
Canela VH, Bowen WS, Ferreira RM, Syed F, Lingeman JE, Sabo AR, Barwinska D, Winfree S, Lake BB, Cheng YH, Gaut JP, Ferkowicz M, LaFavers KA, Zhang K, Coe FL, Worcester E; Kidney Precision Medicine Project; Jain S, Eadon MT, Williams JC Jr, El-Achkar TM. Canela VH, et al. Among authors: winfree s. Nat Commun. 2023 Jul 19;14(1):4140. doi: 10.1038/s41467-023-38975-8. Nat Commun. 2023. PMID: 37468493 Free PMC article.
Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney.
Micanovic R, Khan S, Janosevic D, Lee ME, Hato T, Srour EF, Winfree S, Ghosh J, Tong Y, Rice SE, Dagher PC, Wu XR, El-Achkar TM. Micanovic R, et al. Among authors: winfree s. J Am Soc Nephrol. 2018 Mar;29(3):841-856. doi: 10.1681/ASN.2017040409. Epub 2017 Nov 27. J Am Soc Nephrol. 2018. PMID: 29180395 Free PMC article.
Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel.
LaFavers KA, Macedo E, Garimella PS, Lima C, Khan S, Myslinski J, McClintick J, Witzmann FA, Winfree S, Phillips CL, Hato T, Dagher PC, Wu XR, El-Achkar TM, Micanovic R. LaFavers KA, et al. Among authors: winfree s. Sci Transl Med. 2019 Oct 2;11(512):eaaw3639. doi: 10.1126/scitranslmed.aaw3639. Sci Transl Med. 2019. PMID: 31578243 Free PMC article.
A Precision Medicine Approach Uncovers a Unique Signature of Neutrophils in Patients With Brushite Kidney Stones.
Makki MS, Winfree S, Lingeman JE, Witzmann FA, Worcester EM, Krambeck AE, Coe FL, Evan AP, Bledsoe S, Bergsland KJ, Khochare S, Barwinska D, Williams JC Jr, El-Achkar TM. Makki MS, et al. Among authors: winfree s. Kidney Int Rep. 2020 Feb 20;5(5):663-677. doi: 10.1016/j.ekir.2020.02.1025. eCollection 2020 May. Kidney Int Rep. 2020. PMID: 32405588 Free PMC article.
A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project.
El-Achkar TM, Eadon MT, Menon R, Lake BB, Sigdel TK, Alexandrov T, Parikh S, Zhang G, Dobi D, Dunn KW, Otto EA, Anderton CR, Carson JM, Luo J, Park C, Hamidi H, Zhou J, Hoover P, Schroeder A, Joanes M, Azeloglu EU, Sealfon R, Winfree S, Steck B, He Y, D'Agati V, Iyengar R, Troyanskaya OG, Barisoni L, Gaut J, Zhang K, Laszik Z, Rovin BH, Dagher PC, Sharma K, Sarwal MM, Hodgin JB, Alpers CE, Kretzler M, Jain S. El-Achkar TM, et al. Among authors: winfree s. Physiol Genomics. 2021 Jan 1;53(1):1-11. doi: 10.1152/physiolgenomics.00104.2020. Epub 2020 Nov 16. Physiol Genomics. 2021. PMID: 33197228 Free PMC article.
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