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A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity.
Woodrum BW, Maxwell J, Allen DM, Wilson J, Krumpe LR, Bobkov AA, Hill RB, Kibler KV, O'Keefe BR, Ghirlanda G. Woodrum BW, et al. Among authors: wilson j. Viruses. 2016 Jun 6;8(6):158. doi: 10.3390/v8060158. Viruses. 2016. PMID: 27275831 Free PMC article.
Cyanovirin-N binds to select SARS-CoV-2 spike oligosaccharides outside of the receptor binding domain and blocks infection by SARS-CoV-2.
Muñoz-Basagoiti J, Monteiro FLL, Krumpe LRH, Armario-Najera V, Shenoy SR, Perez-Zsolt D, Westgarth HJ, Villorbina G, Bomfim LM, Raïch-Regué D, Nogueras L, Henrich CJ, Gallemí M, Moreira FRR, Torres P, Wilson J, D'arc M, Marfil S, Herlinger AL, Pradenas E, Higa LM, Portero-Otin M, Trinité B, Twyman RM, Capell T, Tanuri A, Blanco J, Izquierdo-Useros N, Rech EL, Christou P, O'Keefe BR. Muñoz-Basagoiti J, et al. Among authors: wilson j. Proc Natl Acad Sci U S A. 2023 Mar 7;120(10):e2214561120. doi: 10.1073/pnas.2214561120. Epub 2023 Feb 28. Proc Natl Acad Sci U S A. 2023. PMID: 36853940 Free PMC article.
An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics.
Borhani SG, Levine MZ, Krumpe LH, Wilson J, Henrich CJ, O'Keefe BR, Lo DC, Sittampalam GS, Godfrey AG, Lunsford RD, Mangalampalli V, Tao D, LeClair CA, Thole AP, Frey D, Swartz J, Rao G. Borhani SG, et al. Among authors: wilson j. N Biotechnol. 2023 Sep 25;76:13-22. doi: 10.1016/j.nbt.2023.04.003. Epub 2023 Apr 11. N Biotechnol. 2023. PMID: 37054948 Free PMC article.
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