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Page 1
Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy.
Chancellor DR, Davies KE, De Moor O, Dorgan CR, Johnson PD, Lambert AG, Lawrence D, Lecci C, Maillol C, Middleton PJ, Nugent G, Poignant SD, Potter AC, Price PD, Pye RJ, Storer R, Tinsley JM, van Well R, Vickers R, Vile J, Wilkes FJ, Wilson FX, Wren SP, Wynne GM. Chancellor DR, et al. Among authors: wilson fx. J Med Chem. 2011 May 12;54(9):3241-50. doi: 10.1021/jm200135z. Epub 2011 Apr 15. J Med Chem. 2011. PMID: 21456623
Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.
Vuorinen A, Wilkinson IVL, Chatzopoulou M, Edwards B, Squire SE, Fairclough RJ, Bazan NA, Milner JA, Conole D, Donald JR, Shah N, Willis NJ, Martínez RF, Wilson FX, Wynne GM, Davies SG, Davies KE, Russell AJ. Vuorinen A, et al. Among authors: wilson fx. Eur J Med Chem. 2021 Aug 5;220:113431. doi: 10.1016/j.ejmech.2021.113431. Epub 2021 Apr 20. Eur J Med Chem. 2021. PMID: 33915371
Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy.
Chatzopoulou M, Conole D, Emer E, Rowley JA, Willis NJ, Squire SE, Gill B, Brough S, Wilson FX, Wynne GM, Davies SG, Davies KE, Russell AJ. Chatzopoulou M, et al. Among authors: wilson fx. Bioorg Med Chem. 2022 Sep 1;69:116812. doi: 10.1016/j.bmc.2022.116812. Epub 2022 May 18. Bioorg Med Chem. 2022. PMID: 35772287 Free article.
Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse.
Tinsley JM, Fairclough RJ, Storer R, Wilkes FJ, Potter AC, Squire SE, Powell DS, Cozzoli A, Capogrosso RF, Lambert A, Wilson FX, Wren SP, De Luca A, Davies KE. Tinsley JM, et al. Among authors: wilson fx. PLoS One. 2011 May 6;6(5):e19189. doi: 10.1371/journal.pone.0019189. PLoS One. 2011. PMID: 21573153 Free PMC article.
Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy.
De Moor O, Dorgan CR, Johnson PD, Lambert AG, Lecci C, Maillol C, Nugent G, Poignant SD, Price PD, Pye RJ, Storer R, Tinsley JM, Vickers R, Well Rv, Wilkes FJ, Wilson FX, Wren SP, Wynne GM. De Moor O, et al. Among authors: wilson fx. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4828-31. doi: 10.1016/j.bmcl.2011.06.047. Epub 2011 Jun 17. Bioorg Med Chem Lett. 2011. PMID: 21741236
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid.
Chatzopoulou M, Claridge TDW, Davies KE, Davies SG, Elsey DJ, Emer E, Fletcher AM, Harriman S, Robinson N, Rowley JA, Russell AJ, Tinsley JM, Weaver R, Wilkinson IVL, Willis NJ, Wilson FX, Wynne GM. Chatzopoulou M, et al. Among authors: wilson fx. J Med Chem. 2020 Mar 12;63(5):2547-2556. doi: 10.1021/acs.jmedchem.9b01547. Epub 2019 Oct 25. J Med Chem. 2020. PMID: 31599580
2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy.
Babbs A, Berg A, Chatzopoulou M, Davies KE, Davies SG, Edwards B, Elsey DJ, Emer E, Guiraud S, Harriman S, Lecci C, Moir L, Peters D, Robinson N, Rowley JA, Russell AJ, Squire SE, Tinsley JM, Wilson FX, Wynne GM. Babbs A, et al. Among authors: wilson fx. J Med Chem. 2020 Jul 23;63(14):7880-7891. doi: 10.1021/acs.jmedchem.0c00807. Epub 2020 Jul 10. J Med Chem. 2020. PMID: 32551645
Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.
Chatzopoulou M, Emer E, Lecci C, Rowley JA, Casagrande AS, Moir L, Squire SE, Davies SG, Harriman S, Wynne GM, Wilson FX, Davies KE, Russell AJ. Chatzopoulou M, et al. Among authors: wilson fx. ACS Med Chem Lett. 2020 Nov 4;11(12):2421-2427. doi: 10.1021/acsmedchemlett.0c00405. eCollection 2020 Dec 10. ACS Med Chem Lett. 2020. PMID: 33335663 Free PMC article.
Second-generation compound for the modulation of utrophin in the therapy of DMD.
Guiraud S, Squire SE, Edwards B, Chen H, Burns DT, Shah N, Babbs A, Davies SG, Wynne GM, Russell AJ, Elsey D, Wilson FX, Tinsley JM, Davies KE. Guiraud S, et al. Among authors: wilson fx. Hum Mol Genet. 2015 Aug 1;24(15):4212-24. doi: 10.1093/hmg/ddv154. Epub 2015 May 1. Hum Mol Genet. 2015. PMID: 25935002 Free PMC article.
38 results