Willson TM - Search Results

1

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.

Pariollaud M, Gibbs JE, Hopwood TW, Brown S, Begley N, Vonslow R, Poolman T, Guo B, Saer B, Jones DH, Tellam JP, Bresciani S, Tomkinson NC, Wojno-Picon J, Cooper AW, Daniels DA, Trump RP, Grant D, Zuercher W, Willson TM, MacDonald AS, Bolognese B, Podolin PL, Sanchez Y, Loudon AS, Ray DW. Pariollaud M, et al. Among authors: willson tm. J Clin Invest. 2018 Jun 1;128(6):2281-2296. doi: 10.1172/JCI93910. Epub 2018 Apr 30. J Clin Invest. 2018. PMID: 29533925 Free PMC article.

2

Differential activity of rosiglitazone enantiomers at PPAR gamma.

Parks DJ, Tomkinson NC, Villeneuve MS, Blanchard SG, Willson TM. Parks DJ, et al. Among authors: willson tm. Bioorg Med Chem Lett. 1998 Dec 15;8(24):3657-8. doi: 10.1016/s0960-894x(98)00664-7. Bioorg Med Chem Lett. 1998. PMID: 9934490

3

A ligand-mediated hydrogen bond network required for the activation of the mineralocorticoid receptor.

Bledsoe RK, Madauss KP, Holt JA, Apolito CJ, Lambert MH, Pearce KH, Stanley TB, Stewart EL, Trump RP, Willson TM, Williams SP. Bledsoe RK, et al. Among authors: willson tm. J Biol Chem. 2005 Sep 2;280(35):31283-93. doi: 10.1074/jbc.M504098200. Epub 2005 Jun 20. J Biol Chem. 2005. PMID: 15967794 Free article.

4

Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.

Chao EY, Collins JL, Gaillard S, Miller AB, Wang L, Orband-Miller LA, Nolte RT, McDonnell DP, Willson TM, Zuercher WJ. Chao EY, et al. Among authors: willson tm. Bioorg Med Chem Lett. 2006 Feb 15;16(4):821-4. doi: 10.1016/j.bmcl.2005.11.030. Epub 2005 Nov 22. Bioorg Med Chem Lett. 2006. PMID: 16307879

5

X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation.

Wang L, Zuercher WJ, Consler TG, Lambert MH, Miller AB, Orband-Miller LA, McKee DD, Willson TM, Nolte RT. Wang L, et al. Among authors: willson tm. J Biol Chem. 2006 Dec 8;281(49):37773-81. doi: 10.1074/jbc.M608410200. Epub 2006 Sep 21. J Biol Chem. 2006. PMID: 16990259 Free article.

6

Design and synthesis of an array of selective androgen receptor modulators.

Trump RP, Blanc JB, Stewart EL, Brown PJ, Caivano M, Gray DW, Hoekstra WJ, Willson TM, Han B, Turnbull P. Trump RP, et al. Among authors: willson tm. J Comb Chem. 2007 Jan-Feb;9(1):107-14. doi: 10.1021/cc060096e. J Comb Chem. 2007. PMID: 17206838

7

Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.

Xue Y, Chao E, Zuercher WJ, Willson TM, Collins JL, Redinbo MR. Xue Y, et al. Among authors: willson tm. Bioorg Med Chem. 2007 Mar 1;15(5):2156-66. doi: 10.1016/j.bmc.2006.12.026. Epub 2006 Dec 20. Bioorg Med Chem. 2007. PMID: 17215127 Free PMC article.

8

Co-crystal structure guided array synthesis of PPARgamma inverse agonists.

Trump RP, Cobb JE, Shearer BG, Lambert MH, Nolte RT, Willson TM, Buckholz RG, Zhao SM, Leesnitzer LM, Iannone MA, Pearce KH, Billin AN, Hoekstra WJ. Trump RP, et al. Among authors: willson tm. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3916-20. doi: 10.1016/j.bmcl.2007.04.111. Epub 2007 May 18. Bioorg Med Chem Lett. 2007. PMID: 17533125

9

On the intractability of estrogen-related receptor alpha as a target for activation by small molecules.

Hyatt SM, Lockamy EL, Stein RA, McDonnell DP, Miller AB, Orband-Miller LA, Willson TM, Zuercher WJ. Hyatt SM, et al. Among authors: willson tm. J Med Chem. 2007 Dec 27;50(26):6722-4. doi: 10.1021/jm7012387. Epub 2007 Dec 4. J Med Chem. 2007. PMID: 18052088 Free PMC article.

10

GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα.

Grant D, Yin L, Collins JL, Parks DJ, Orband-Miller LA, Wisely GB, Joshi S, Lazar MA, Willson TM, Zuercher WJ. Grant D, et al. Among authors: willson tm. ACS Chem Biol. 2010 Oct 15;5(10):925-32. doi: 10.1021/cb100141y. ACS Chem Biol. 2010. PMID: 20677822

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