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Structure-guided design of a selective inhibitor of the methyltransferase KMT9 with cellular activity.
Wang S, Klein SO, Urban S, Staudt M, Barthes NPF, Willmann D, Bacher J, Sum M, Bauer H, Peng L, Rennar GA, Gratzke C, Schüle KM, Zhang L, Einsle O, Greschik H, MacLeod C, Thomson CG, Jung M, Metzger E, Schüle R. Wang S, et al. Among authors: willmann d. Nat Commun. 2024 Jan 2;15(1):43. doi: 10.1038/s41467-023-44243-6. Nat Commun. 2024. PMID: 38167811 Free PMC article.
LSD1 promotes oxidative metabolism of white adipose tissue.
Duteil D, Metzger E, Willmann D, Karagianni P, Friedrichs N, Greschik H, Günther T, Buettner R, Talianidis I, Metzger D, Schüle R. Duteil D, et al. Among authors: willmann d. Nat Commun. 2014 Jun 10;5:4093. doi: 10.1038/ncomms5093. Nat Commun. 2014. PMID: 24912735 Free PMC article.
The histone code reader SPIN1 controls RET signaling in liposarcoma.
Franz H, Greschik H, Willmann D, Ozretić L, Jilg CA, Wardelmann E, Jung M, Buettner R, Schüle R. Franz H, et al. Among authors: willmann d. Oncotarget. 2015 Mar 10;6(7):4773-89. doi: 10.18632/oncotarget.3000. Oncotarget. 2015. PMID: 25749382 Free PMC article.
Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.
Fedorov O, Castex J, Tallant C, Owen DR, Martin S, Aldeghi M, Monteiro O, Filippakopoulos P, Picaud S, Trzupek JD, Gerstenberger BS, Bountra C, Willmann D, Wells C, Philpott M, Rogers C, Biggin PC, Brennan PE, Bunnage ME, Schüle R, Günther T, Knapp S, Müller S. Fedorov O, et al. Among authors: willmann d. Sci Adv. 2015 Nov 13;1(10):e1500723. doi: 10.1126/sciadv.1500723. eCollection 2015 Nov. Sci Adv. 2015. PMID: 26702435 Free PMC article.
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation.
Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, von Maessenhausen A, Urban S, Schott AK, Espejo A, Eberlin A, Wohlwend D, Schüle KM, Schleicher M, Perner S, Bedford MT, Jung M, Dengjel J, Flaig R, Imhof A, Einsle O, Schüle R. Metzger E, et al. Among authors: willmann d. Nat Struct Mol Biol. 2016 Feb;23(2):132-9. doi: 10.1038/nsmb.3153. Epub 2016 Jan 11. Nat Struct Mol Biol. 2016. PMID: 26751641
30 results