Williams RL - Search Results

1

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.

Gong GQ, Bilanges B, Allsop B, Masson GR, Roberton V, Askwith T, Oxenford S, Madsen RR, Conduit SE, Bellini D, Fitzek M, Collier M, Najam O, He Z, Wahab B, McLaughlin SH, Chan AWE, Feierberg I, Madin A, Morelli D, Bhamra A, Vinciauskaite V, Anderson KE, Surinova S, Pinotsis N, Lopez-Guadamillas E, Wilcox M, Hooper A, Patel C, Whitehead MA, Bunney TD, Stephens LR, Hawkins PT, Katan M, Yellon DM, Davidson SM, Smith DM, Phillips JB, Angell R, Williams RL, Vanhaesebroeck B. Gong GQ, et al. Among authors: williams rl. Nature. 2023 Jun;618(7963):159-168. doi: 10.1038/s41586-023-05972-2. Epub 2023 May 24. Nature. 2023. PMID: 37225977 Free PMC article.

2

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta.

Essen LO, Perisic O, Cheung R, Katan M, Williams RL. Essen LO, et al. Among authors: williams rl. Nature. 1996 Apr 18;380(6575):595-602. doi: 10.1038/380595a0. Nature. 1996. PMID: 8602259

3

Structural views of phosphoinositide-specific phospholipase C: signalling the way ahead.

Williams RL, Katan M. Williams RL, et al. Structure. 1996 Dec 15;4(12):1387-94. doi: 10.1016/s0969-2126(96)00146-3. Structure. 1996. PMID: 8994965 Free article. Review.

4

Phosphoinositide-specific phospholipase C: structural basis for catalysis and regulatory interactions.

Katan M, Williams RL. Katan M, et al. Among authors: williams rl. Semin Cell Dev Biol. 1997 Jun;8(3):287-296. doi: 10.1006/scdb.1997.0150. Semin Cell Dev Biol. 1997. PMID: 10024492

5

Structural insights into phosphoinositide 3-kinase catalysis and signalling.

Walker EH, Perisic O, Ried C, Stephens L, Williams RL. Walker EH, et al. Among authors: williams rl. Nature. 1999 Nov 18;402(6759):313-20. doi: 10.1038/46319. Nature. 1999. PMID: 10580505

6

Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.

Walker EH, Pacold ME, Perisic O, Stephens L, Hawkins PT, Wymann MP, Williams RL. Walker EH, et al. Among authors: williams rl. Mol Cell. 2000 Oct;6(4):909-19. doi: 10.1016/s1097-2765(05)00089-4. Mol Cell. 2000. PMID: 11090628 Free article.

7

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.

Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, Hawkins PT, Stephens L, Eccleston JF, Williams RL. Pacold ME, et al. Among authors: williams rl. Cell. 2000 Dec 8;103(6):931-43. doi: 10.1016/s0092-8674(00)00196-3. Cell. 2000. PMID: 11136978 Free article.

8

The crystal structure of the PX domain from p40(phox) bound to phosphatidylinositol 3-phosphate.

Bravo J, Karathanassis D, Pacold CM, Pacold ME, Ellson CD, Anderson KE, Butler PJ, Lavenir I, Perisic O, Hawkins PT, Stephens L, Williams RL. Bravo J, et al. Among authors: williams rl. Mol Cell. 2001 Oct;8(4):829-39. doi: 10.1016/s1097-2765(01)00372-0. Mol Cell. 2001. PMID: 11684018 Free article.

9

ARAP3 is a PI3K- and rap-regulated GAP for RhoA.

Krugmann S, Williams R, Stephens L, Hawkins PT. Krugmann S, et al. Curr Biol. 2004 Aug 10;14(15):1380-4. doi: 10.1016/j.cub.2004.07.058. Curr Biol. 2004. PMID: 15296756 Free article.

10

The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase.

Perisic O, Wilson MI, Karathanassis D, Bravo J, Pacold ME, Ellson CD, Hawkins PT, Stephens L, Williams RL. Perisic O, et al. Among authors: williams rl. Adv Enzyme Regul. 2004;44:279-98. doi: 10.1016/j.advenzreg.2003.11.003. Adv Enzyme Regul. 2004. PMID: 15581496 Review. No abstract available.

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