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Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1.
Vollmer KJ, Burns AC, Sauer HE, Williams JD, Komazin-Meredith G, Cardinale S, Butler M, Aron Z, Hussein I, Busch MG, Bowlin TL, Gentry BG. Vollmer KJ, et al. Among authors: williams jd. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01301-19. doi: 10.1128/AAC.01301-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31332074 Free PMC article.
Synthesis and antiviral activities of methylenecyclopropane analogs with 6-alkoxy and 6-alkylthio substitutions that exhibit broad-spectrum antiviral activity against human herpesviruses.
Prichard MN, Williams JD, Komazin-Meredith G, Khan AR, Price NB, Jefferson GM, Harden EA, Hartline CB, Peet NP, Bowlin TL. Prichard MN, et al. Among authors: williams jd. Antimicrob Agents Chemother. 2013 Aug;57(8):3518-27. doi: 10.1128/AAC.00429-13. Epub 2013 May 13. Antimicrob Agents Chemother. 2013. PMID: 23669381 Free PMC article.
Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions.
Komazin-Meredith G, Chou S, Prichard MN, Hartline CB, Cardinale SC, Comeau K, Williams JD, Khan AR, Peet NP, Bowlin TL. Komazin-Meredith G, et al. Among authors: williams jd. Antimicrob Agents Chemother. 2014;58(1):274-8. doi: 10.1128/AAC.01726-13. Epub 2013 Oct 21. Antimicrob Agents Chemother. 2014. PMID: 24145545 Free PMC article.
TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.
Komazin-Meredith G, Cardinale SC, Comeau K, Magalhaes KJ, Hartline CB, Williams JD, Opperman TJ, Prichard MN, Bowlin TL. Komazin-Meredith G, et al. Among authors: williams jd. Antiviral Res. 2015 Jul;119:23-7. doi: 10.1016/j.antiviral.2015.04.001. Epub 2015 Apr 7. Antiviral Res. 2015. PMID: 25857706 Free PMC article.
Mutations in the Pseudomonas aeruginosa needle protein gene pscF confer resistance to phenoxyacetamide inhibitors of the type III secretion system.
Bowlin NO, Williams JD, Knoten CA, Torhan MC, Tashjian TF, Li B, Aiello D, Mecsas J, Hauser AR, Peet NP, Bowlin TL, Moir DT. Bowlin NO, et al. Among authors: williams jd. Antimicrob Agents Chemother. 2014;58(4):2211-20. doi: 10.1128/AAC.02795-13. Epub 2014 Jan 27. Antimicrob Agents Chemother. 2014. PMID: 24468789 Free PMC article.
840 results