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459 results

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Page 1
Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression.
Luk IY, Jenkins LJ, Schoffer KL, Ng I, Tse JWT, Mouradov D, Kaczmarczyk S, Nightingale R, Burrows AD, Anderson RL, Arango D, Dopeso H, Croft L, Richardson MF, Sieber OM, Liao Y, Mooi JK, Vukelic N, Reehorst CM, Afshar-Sterle S, Whitehall VLJ, Fennell L, Abud HE, Tebbutt NC, Phillips WA, Williams DS, Shi W, Mielke LA, Ernst M, Dhillon AS, Clemons NJ, Mariadason JM. Luk IY, et al. Among authors: williams ds. Cell Death Differ. 2022 Nov;29(11):2288-2302. doi: 10.1038/s41418-022-01016-w. Epub 2022 May 23. Cell Death Differ. 2022. PMID: 35606410 Free PMC article.
Intestinal epithelial-specific PTEN inactivation results in tumor formation.
Byun DS, Ahmed N, Nasser S, Shin J, Al-Obaidi S, Goel S, Corner GA, Wilson AJ, Flanagan DJ, Williams DS, Augenlicht LH, Vincan E, Mariadason JM. Byun DS, et al. Among authors: williams ds. Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G856-64. doi: 10.1152/ajpgi.00178.2011. Epub 2011 Aug 11. Am J Physiol Gastrointest Liver Physiol. 2011. PMID: 21836055 Free PMC article.
Villin expression is frequently lost in poorly differentiated colon cancer.
Arango D, Al-Obaidi S, Williams DS, Dopeso H, Mazzolini R, Corner G, Byun DS, Carr AA, Murone C, Tögel L, Zeps N, Aaltonen LA, Iacopetta B, Mariadason JM. Arango D, et al. Among authors: williams ds. Am J Pathol. 2012 Apr;180(4):1509-21. doi: 10.1016/j.ajpath.2012.01.006. Epub 2012 Feb 18. Am J Pathol. 2012. PMID: 22349300 Free PMC article.
DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.
Tögel L, Nightingale R, Wu R, Chüeh AC, Al-Obaidi S, Luk I, Dávalos-Salas M, Chionh F, Murone C, Buchanan DD, Chatterton Z, Sieber OM, Arango D, Tebbutt NC, Williams D, Dhillon AS, Mariadason JM. Tögel L, et al. Sci Rep. 2018 Jan 29;8(1):1767. doi: 10.1038/s41598-018-20176-9. Sci Rep. 2018. PMID: 29379130 Free PMC article.
Lymphocytic response to tumour and deficient DNA mismatch repair identify subtypes of stage II/III colorectal cancer associated with patient outcomes.
Williams DS, Mouradov D, Jorissen RN, Newman MR, Amini E, Nickless DK, Teague JA, Fang CG, Palmieri M, Parsons MJ, Sakthianandeswaren A, Li S, Ward RL, Hawkins NJ, Faragher I, Jones IT, Gibbs P, Sieber OM. Williams DS, et al. Gut. 2019 Mar;68(3):465-474. doi: 10.1136/gutjnl-2017-315664. Epub 2018 Jan 30. Gut. 2019. PMID: 29382774
The prognostic impact of consensus molecular subtypes (CMS) and its predictive effects for bevacizumab benefit in metastatic colorectal cancer: molecular analysis of the AGITG MAX clinical trial.
Mooi JK, Wirapati P, Asher R, Lee CK, Savas P, Price TJ, Townsend A, Hardingham J, Buchanan D, Williams D, Tejpar S, Mariadason JM, Tebbutt NC. Mooi JK, et al. Ann Oncol. 2018 Nov 1;29(11):2240-2246. doi: 10.1093/annonc/mdy410. Ann Oncol. 2018. PMID: 30247524 Free article. Clinical Trial.
Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer.
Williams DS, Mouradov D, Browne C, Palmieri M, Elliott MJ, Nightingale R, Fang CG, Li R, Mariadason JM, Faragher I, Jones IT, Churilov L, Tebbutt NC, Gibbs P, Sieber OM. Williams DS, et al. Mod Pathol. 2020 Mar;33(3):483-495. doi: 10.1038/s41379-019-0353-2. Epub 2019 Aug 30. Mod Pathol. 2020. PMID: 31471586 Free article.
Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets.
Lau DK, Mouradov D, Wasenang W, Luk IY, Scott CM, Williams DS, Yeung YH, Limpaiboon T, Iatropoulos GF, Jenkins LJ, Reehorst CM, Chionh F, Nikfarjam M, Croagh D, Dhillon AS, Weickhardt AJ, Muramatsu T, Saito Y, Tebbutt NC, Sieber OM, Mariadason JM. Lau DK, et al. Among authors: williams ds. iScience. 2019 Nov 22;21:624-637. doi: 10.1016/j.isci.2019.10.044. Epub 2019 Oct 31. iScience. 2019. PMID: 31731200 Free PMC article.
Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity.
Dávalos-Salas M, Montgomery MK, Reehorst CM, Nightingale R, Ng I, Anderton H, Al-Obaidi S, Lesmana A, Scott CM, Ioannidis P, Kalra H, Keerthikumar S, Tögel L, Rigopoulos A, Gong SJ, Williams DS, Yoganantharaja P, Bell-Anderson K, Mathivanan S, Gibert Y, Hiebert S, Scott AM, Watt MJ, Mariadason JM. Dávalos-Salas M, et al. Among authors: williams ds. Nat Commun. 2019 Nov 22;10(1):5291. doi: 10.1038/s41467-019-13180-8. Nat Commun. 2019. PMID: 31757939 Free PMC article.
459 results