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Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.
Bell CC, Dankers ACA, Lauschke VM, Sison-Young R, Jenkins R, Rowe C, Goldring CE, Park K, Regan SL, Walker T, Schofield C, Baze A, Foster AJ, Williams DP, van de Ven AWM, Jacobs F, Houdt JV, Lähteenmäki T, Snoeys J, Juhila S, Richert L, Ingelman-Sundberg M. Bell CC, et al. Among authors: williams dp. Toxicol Sci. 2018 Apr 1;162(2):655-666. doi: 10.1093/toxsci/kfx289. Toxicol Sci. 2018. PMID: 29329425 Free PMC article.
The role of metabolic activation in drug-induced hepatotoxicity.
Park BK, Kitteringham NR, Maggs JL, Pirmohamed M, Williams DP. Park BK, et al. Among authors: williams dp. Annu Rev Pharmacol Toxicol. 2005;45:177-202. doi: 10.1146/annurev.pharmtox.45.120403.100058. Annu Rev Pharmacol Toxicol. 2005. PMID: 15822174 Review.
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A, Hewitt PG, Ingelman-Sundberg M, Jensen KG, Juhila S, Klingmüller U, Labbe G, Liguori MJ, Lovatt CA, Morgan P, Naisbitt DJ, Pieters RHH, Snoeys J, van de Water B, Williams DP, Park BK. Weaver RJ, et al. Among authors: williams dp. Nat Rev Drug Discov. 2020 Feb;19(2):131-148. doi: 10.1038/s41573-019-0048-x. Epub 2019 Nov 20. Nat Rev Drug Discov. 2020. PMID: 31748707 Free article. Review.
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid.
Foster AJ, Chouhan B, Regan SL, Rollison H, Amberntsson S, Andersson LC, Srivastava A, Darnell M, Cairns J, Lazic SE, Jang KJ, Petropolis DB, Kodella K, Rubins JE, Williams D, Hamilton GA, Ewart L, Morgan P. Foster AJ, et al. Arch Toxicol. 2019 Apr;93(4):1021-1037. doi: 10.1007/s00204-019-02427-4. Epub 2019 Mar 26. Arch Toxicol. 2019. PMID: 30915487
Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.
Mercer AE, Regan SL, Hirst CM, Graham EE, Antoine DJ, Benson CA, Williams DP, Foster J, Kenna JG, Park BK. Mercer AE, et al. Among authors: williams dp. Toxicol Appl Pharmacol. 2009 Sep 15;239(3):297-305. doi: 10.1016/j.taap.2009.05.027. Epub 2009 Jun 10. Toxicol Appl Pharmacol. 2009. PMID: 19523481
209 results