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Safety pharmacology--current and emerging concepts.
Hamdam J, Sethu S, Smith T, Alfirevic A, Alhaidari M, Atkinson J, Ayala M, Box H, Cross M, Delaunois A, Dermody A, Govindappa K, Guillon JM, Jenkins R, Kenna G, Lemmer B, Meecham K, Olayanju A, Pestel S, Rothfuss A, Sidaway J, Sison-Young R, Smith E, Stebbings R, Tingle Y, Valentin JP, Williams A, Williams D, Park K, Goldring C. Hamdam J, et al. Among authors: williams d, williams a. Toxicol Appl Pharmacol. 2013 Dec 1;273(2):229-41. doi: 10.1016/j.taap.2013.04.039. Epub 2013 Jun 1. Toxicol Appl Pharmacol. 2013. PMID: 23732082 Review.
Investigation of toxic metabolites during drug development.
Park K, Williams DP, Naisbitt DJ, Kitteringham NR, Pirmohamed M. Park K, et al. Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):425-34. doi: 10.1016/j.taap.2005.02.029. Toxicol Appl Pharmacol. 2005. PMID: 15996699 Review.
Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist.
Thaventhiran T, Alhumeed N, Yeang HX, Sethu S, Downey JS, Alghanem AF, Olayanju A, Smith EL, Cross MJ, Webb SD, Williams DP, Bristow A, Ball C, Stebbings R, Sathish JG. Thaventhiran T, et al. Among authors: williams dp. MAbs. 2014;6(5):1290-9. doi: 10.4161/mabs.29758. Epub 2014 Oct 30. MAbs. 2014. PMID: 25517314 Free PMC article.
The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Jolly CE, Douglas O, Kamalian L, Jenkins RE, Beckett AJ, Penman SL, Williams DP, Monshouwer M, Simic D, Snoeys J, Park BK, Chadwick AE. Jolly CE, et al. Among authors: williams dp. Toxicol Appl Pharmacol. 2020 Sep 15;403:115163. doi: 10.1016/j.taap.2020.115163. Epub 2020 Jul 28. Toxicol Appl Pharmacol. 2020. PMID: 32730777 Free PMC article.
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study.
Bell CC, Dankers ACA, Lauschke VM, Sison-Young R, Jenkins R, Rowe C, Goldring CE, Park K, Regan SL, Walker T, Schofield C, Baze A, Foster AJ, Williams DP, van de Ven AWM, Jacobs F, Houdt JV, Lähteenmäki T, Snoeys J, Juhila S, Richert L, Ingelman-Sundberg M. Bell CC, et al. Toxicol Sci. 2018 Apr 1;162(2):655-666. doi: 10.1093/toxsci/kfx289. Toxicol Sci. 2018. PMID: 29329425 Free PMC article.
Toxicophores: investigations in drug safety.
Williams DP. Williams DP. Toxicology. 2006 Sep 1;226(1):1-11. doi: 10.1016/j.tox.2006.05.101. Epub 2006 Jun 9. Toxicology. 2006. PMID: 16860917
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