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Glial function (and dysfunction) in the normal & ischemic brain.
Magaki SD, Williams CK, Vinters HV. Magaki SD, et al. Among authors: williams ck. Neuropharmacology. 2018 May 15;134(Pt B):218-225. doi: 10.1016/j.neuropharm.2017.11.009. Epub 2017 Nov 6. Neuropharmacology. 2018. PMID: 29122627 Free PMC article. Review.
Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
Seidler PM, Boyer DR, Murray KA, Yang TP, Bentzel M, Sawaya MR, Rosenberg G, Cascio D, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Eisenberg DS. Seidler PM, et al. Among authors: williams ck. J Biol Chem. 2019 Nov 1;294(44):16451-16464. doi: 10.1074/jbc.RA119.009688. Epub 2019 Sep 19. J Biol Chem. 2019. PMID: 31537646 Free PMC article.
Inhibition of synucleinopathic seeding by rationally designed inhibitors.
Sangwan S, Sahay S, Murray KA, Morgan S, Guenther EL, Jiang L, Williams CK, Vinters HV, Goedert M, Eisenberg DS. Sangwan S, et al. Among authors: williams ck. Elife. 2020 Jan 2;9:e46775. doi: 10.7554/eLife.46775. Elife. 2020. PMID: 31895037 Free PMC article.
Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, Eisenberg DS. Abskharon R, et al. Among authors: williams ck. J Biol Chem. 2020 Jul 31;295(31):10662-10676. doi: 10.1074/jbc.RA120.013638. Epub 2020 Jun 3. J Biol Chem. 2020. PMID: 32493775 Free PMC article.
Neuropathologic Findings in Chronic Kidney Disease (CKD).
Vinters HV, Magaki SD, Williams CK. Vinters HV, et al. Among authors: williams ck. J Stroke Cerebrovasc Dis. 2021 Sep;30(9):105657. doi: 10.1016/j.jstrokecerebrovasdis.2021.105657. Epub 2021 Feb 10. J Stroke Cerebrovasc Dis. 2021. PMID: 33579545 Review.
267 results