Willems PH - Search Results

1

NDUFA2 complex I mutation leads to Leigh disease.

Hoefs SJ, Dieteren CE, Distelmaier F, Janssen RJ, Epplen A, Swarts HG, Forkink M, Rodenburg RJ, Nijtmans LG, Willems PH, Smeitink JA, van den Heuvel LP. Hoefs SJ, et al. Among authors: willems ph. Am J Hum Genet. 2008 Jun;82(6):1306-15. doi: 10.1016/j.ajhg.2008.05.007. Am J Hum Genet. 2008. PMID: 18513682 Free PMC article.

2

Conformation-dependent inhibition of gastric H+,K+-ATPase by SCH 28080 demonstrated by mutagenesis of glutamic acid 820.

Swarts HG, Hermsen HP, Koenderink JB, Willems PH, de Pont JJ. Swarts HG, et al. Among authors: willems ph. Mol Pharmacol. 1999 Mar;55(3):541-7. Mol Pharmacol. 1999. PMID: 10051539

3

Mutation of aspartate 804 of Na(+),K(+)-ATPase modifies the cation binding pocket and thereby generates a high Na(+)-ATPase activity.

Koenderink JB, Swarts HG, Hermsen HP, Willems PH, De Pont JJ. Koenderink JB, et al. Among authors: willems ph. Biochemistry. 2000 Aug 15;39(32):9959-66. doi: 10.1021/bi0001168. Biochemistry. 2000. PMID: 10933816

4

High-affinity ouabain binding by a chimeric gastric H+,K+-ATPase containing transmembrane hairpins M3-M4 and M5-M6 of the alpha 1-subunit of rat Na+,K+-ATPase.

Koenderink JB, Hermsen HP, Swarts HG, Willems PH, De Pont JJ. Koenderink JB, et al. Among authors: willems ph. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11209-14. doi: 10.1073/pnas.200109597. Proc Natl Acad Sci U S A. 2000. PMID: 11016952 Free PMC article.

5

Chimeras of X+, K+-ATPases. The M1-M6 region of Na+, K+-ATPase is required for Na+-activated ATPase activity, whereas the M7-M10 region of H+, K+-ATPase is involved in K+ de-occlusion.

Koenderink JB, Swarts HG, Stronks HC, Hermsen HP, Willems PH, De Pont JJ. Koenderink JB, et al. Among authors: willems ph. J Biol Chem. 2001 Apr 13;276(15):11705-11. doi: 10.1074/jbc.M010804200. Epub 2001 Jan 16. J Biol Chem. 2001. PMID: 11278751 Free article.

6

Mimicking of K+ activation by double mutation of glutamate 795 and glutamate 820 of gastric H+,K+-ATPase.

Hermsen HP, Swarts HG, Wassink L, Koenderink JB, Willems PH, De Pont JJ. Hermsen HP, et al. Among authors: willems ph. Biochemistry. 2001 May 29;40(21):6527-33. doi: 10.1021/bi002456z. Biochemistry. 2001. PMID: 11371216

7

K(+)-independent gastric H(+),K(+)-atpase activity. Dissociation of K(+)-independent dephosphorylation and preference for the E1 conformation by combined mutagenesis of transmembrane glutamate residues.

Swarts HG, Koenderink JB, Hermsen HP, Willems PH, De Pont JJ. Swarts HG, et al. Among authors: willems ph. J Biol Chem. 2001 Oct 5;276(40):36909-16. doi: 10.1074/jbc.M103945200. Epub 2001 Jul 24. J Biol Chem. 2001. PMID: 11470785 Free article.

8

The E1/E2-preference of gastric H,K-ATPase mutants.

De Pont JJ, Swarts HG, Willems PH, Koenderink JB. De Pont JJ, et al. Among authors: willems ph. Ann N Y Acad Sci. 2003 Apr;986:175-82. doi: 10.1111/j.1749-6632.2003.tb07157.x. Ann N Y Acad Sci. 2003. PMID: 12763793

9

Mutational analysis of ouabain interaction with the M5-M6 hairpin of Na,K-ATPase.

Qiu LY, Koenderink JB, Swarts HG, Willems PH, De Pont JJ. Qiu LY, et al. Among authors: willems ph. Ann N Y Acad Sci. 2003 Apr;986:255-7. doi: 10.1111/j.1749-6632.2003.tb07176.x. Ann N Y Acad Sci. 2003. PMID: 12763812 No abstract available.

10

The role of Lys791 and Asn792 in gastric H,K-ATPase.

Swarts HG, Willems PH, Koenderink JB, De Pont JJ. Swarts HG, et al. Among authors: willems ph. Ann N Y Acad Sci. 2003 Apr;986:308-9. doi: 10.1111/j.1749-6632.2003.tb07196.x. Ann N Y Acad Sci. 2003. PMID: 12763832 No abstract available.

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