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The β-Secretase BACE1 in Alzheimer's Disease.
Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R, Vanmechelen E, De Vos A, Nisticò R, Corbo M, Imbimbo BP, Streffer J, Voytyuk I, Timmers M, Tahami Monfared AA, Irizarry M, Albala B, Koyama A, Watanabe N, Kimura T, Yarenis L, Lista S, Kramer L, Vergallo A. Hampel H, et al. Among authors: willem m. Biol Psychiatry. 2021 Apr 15;89(8):745-756. doi: 10.1016/j.biopsych.2020.02.001. Epub 2020 Feb 13. Biol Psychiatry. 2021. PMID: 32223911 Free PMC article. Review.
Maturation and pro-peptide cleavage of beta-secretase.
Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C. Capell A, et al. Among authors: willem m. J Biol Chem. 2000 Oct 6;275(40):30849-54. doi: 10.1074/jbc.M003202200. J Biol Chem. 2000. PMID: 10801872 Free article.
Phosphorylation regulates intracellular trafficking of beta-secretase.
Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C. Walter J, et al. Among authors: willem m. J Biol Chem. 2001 May 4;276(18):14634-41. doi: 10.1074/jbc.M011116200. Epub 2001 Jan 29. J Biol Chem. 2001. PMID: 11278841 Free article.
Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.
Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C. Westmeyer GG, et al. Among authors: willem m. J Biol Chem. 2004 Dec 17;279(51):53205-12. doi: 10.1074/jbc.M410378200. Epub 2004 Oct 12. J Biol Chem. 2004. PMID: 15485862 Free article.
Control of peripheral nerve myelination by the beta-secretase BACE1.
Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C. Willem M, et al. Science. 2006 Oct 27;314(5799):664-6. doi: 10.1126/science.1132341. Epub 2006 Sep 21. Science. 2006. PMID: 16990514
Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.
Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge R, De Strooper B. Dejaegere T, et al. Among authors: willem m. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9775-80. doi: 10.1073/pnas.0800507105. Epub 2008 Jul 14. Proc Natl Acad Sci U S A. 2008. PMID: 18626010 Free PMC article.
BACE1 dependent neuregulin processing: review.
Fleck D, Garratt AN, Haass C, Willem M. Fleck D, et al. Among authors: willem m. Curr Alzheimer Res. 2012 Feb;9(2):178-83. doi: 10.2174/156720512799361637. Curr Alzheimer Res. 2012. PMID: 22455478 Review.
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