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The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases.
Roatsch M, Hoffmann I, Abboud MI, Hancock RL, Tarhonskaya H, Hsu KF, Wilkins SE, Yeh TL, Lippl K, Serrer K, Moneke I, Ahrens TD, Robaa D, Wenzler S, Barthes NPF, Franz H, Sippl W, Lassmann S, Diederichs S, Schleicher E, Schofield CJ, Kawamura A, Schüle R, Jung M. Roatsch M, et al. Among authors: wilkins se. ACS Chem Biol. 2019 Aug 16;14(8):1737-1750. doi: 10.1021/acschembio.9b00289. Epub 2019 Jul 19. ACS Chem Biol. 2019. PMID: 31287655
Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.
Thinnes CC, Tumber A, Yapp C, Scozzafava G, Yeh T, Chan MC, Tran TA, Hsu K, Tarhonskaya H, Walport LJ, Wilkins SE, Martinez ED, Müller S, Pugh CW, Ratcliffe PJ, Brennan PE, Kawamura A, Schofield CJ. Thinnes CC, et al. Among authors: wilkins se. Chem Commun (Camb). 2015 Oct 28;51(84):15458-61. doi: 10.1039/c5cc06095h. Chem Commun (Camb). 2015. PMID: 26345662
Targeting Protein-Protein Interactions in the HIF System.
Wilkins SE, Abboud MI, Hancock RL, Schofield CJ. Wilkins SE, et al. ChemMedChem. 2016 Apr 19;11(8):773-86. doi: 10.1002/cmdc.201600012. Epub 2016 Mar 21. ChemMedChem. 2016. PMID: 26997519 Free PMC article. Review.
The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.
Markolovic S, Zhuang Q, Wilkins SE, Eaton CD, Abboud MI, Katz MJ, McNeil HE, Leśniak RK, Hall C, Struwe WB, Konietzny R, Davis S, Yang M, Ge W, Benesch JLP, Kessler BM, Ratcliffe PJ, Cockman ME, Fischer R, Wappner P, Chowdhury R, Coleman ML, Schofield CJ. Markolovic S, et al. Among authors: wilkins se. Nat Chem Biol. 2018 Jul;14(7):688-695. doi: 10.1038/s41589-018-0071-y. Epub 2018 Jun 18. Nat Chem Biol. 2018. PMID: 29915238 Free PMC article.
YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase.
Sekirnik R, Wilkins SE, Bush J, Tarhonskaya H, Münzel M, Hussein A, Flashman E, Mohammed S, McDonough MA, Loenarz C, Schofield CJ. Sekirnik R, et al. Among authors: wilkins se. Extremophiles. 2018 May;22(3):553-562. doi: 10.1007/s00792-018-1016-9. Epub 2018 Mar 9. Extremophiles. 2018. PMID: 29523972 Free PMC article.
JMJD5 is a human arginyl C-3 hydroxylase.
Wilkins SE, Islam MS, Gannon JM, Markolovic S, Hopkinson RJ, Ge W, Schofield CJ, Chowdhury R. Wilkins SE, et al. Nat Commun. 2018 Mar 21;9(1):1180. doi: 10.1038/s41467-018-03410-w. Nat Commun. 2018. PMID: 29563586 Free PMC article.
21 results