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A comprehensive evaluation in clinic and physiologically-based pharmacokinetic modeling and simulation to confirm lack of cytochrome P450-mediated drug-drug interaction potential for pomotrelvir.
Yang Z, Rioux N, Vincent L, Jones HM, Cha D, Plummer A, Wilfret D, Kearney BP. Yang Z, et al. Among authors: wilfret d. CPT Pharmacometrics Syst Pharmacol. 2023 Oct;12(10):1553-1564. doi: 10.1002/psp4.13034. Epub 2023 Aug 30. CPT Pharmacometrics Syst Pharmacol. 2023. PMID: 37614073 Free PMC article.
Characterization of Pharmacokinetics, Biotransformation and Elimination of Pomotrelvir Orally Administered in Healthy Male Adults Using Two [14C]-Labeled Microtracers with Separate Labeling Positions.
Yang Z, Wong SL, Cha D, Wilfret D, Turnquist D, Plummer A, van Ingen E, Kearney BP. Yang Z, et al. Among authors: wilfret d. Drug Metab Dispos. 2023 Dec;51(12):1607-1614. doi: 10.1124/dmd.123.001439. Epub 2023 Sep 8. Drug Metab Dispos. 2023. PMID: 37684056
Resolution of organ dysfunction as a predictor of long-term survival in necrotizing soft tissue infections: Analysis of the AB103 Clinical Composite Endpoint Study in Necrotizing Soft Tissue Infections trial and a retrospective claims database-linked chart study.
Brakenridge SC, Wilfret DA, Maislin G, Andrade KE, Walker V, May AK, Dankner WM, Bulger EM. Brakenridge SC, et al. Among authors: wilfret da. J Trauma Acute Care Surg. 2021 Aug 1;91(2):384-392. doi: 10.1097/TA.0000000000003183. J Trauma Acute Care Surg. 2021. PMID: 33797490 Clinical Trial.
A Novel Immune Modulator for Patients With Necrotizing Soft Tissue Infections (NSTI): Results of a Multicenter, Phase 3 Randomized Controlled Trial of Reltecimod (AB 103).
Bulger EM, May AK, Robinson BRH, Evans DC, Henry S, Green JM, Toschlog E, Sperry JL, Fagenholz P, Martin ND, Dankner WM, Maislin G, Wilfret D, Bernard AC; ACCUTE Study Investigators. Bulger EM, et al. Among authors: wilfret d. Ann Surg. 2020 Sep 1;272(3):469-478. doi: 10.1097/SLA.0000000000004102. Ann Surg. 2020. PMID: 32657946 Clinical Trial.
A randomized, double blind, dose escalation, first time in human study to assess the safety, tolerability, pharmacokinetics, and antiviral activity of single doses of GSK2485852 in chronically infected hepatitis C subjects.
Wilfret DA, Walker J, Voitenleitner C, Baptiste-Brown S, Lovern M, Kim J, Adkison K, Shotwell B, Mathis A, Moss L, Lee D, Yu L, Gan J, Spaltenstein A. Wilfret DA, et al. Clin Pharmacol Drug Dev. 2014 Nov;3(6):439-48. doi: 10.1002/cpdd.142. Epub 2014 Oct 20. Clin Pharmacol Drug Dev. 2014. PMID: 27129119 Clinical Trial.
Effects of enzyme inducers efavirenz and tipranavir/ritonavir on the pharmacokinetics of the HIV integrase inhibitor dolutegravir.
Song I, Borland J, Chen S, Guta P, Lou Y, Wilfret D, Wajima T, Savina P, Peppercorn A, Castellino S, Wagner D, Hosking L, Mosteller M, Rubio JP, Piscitelli SC. Song I, et al. Among authors: wilfret d. Eur J Clin Pharmacol. 2014 Oct;70(10):1173-9. doi: 10.1007/s00228-014-1732-8. Epub 2014 Aug 23. Eur J Clin Pharmacol. 2014. PMID: 25146692 Free PMC article. Clinical Trial.
16 results