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Engineering a Model Cell for Rational Tuning of GPCR Signaling.
Shaw WM, Yamauchi H, Mead J, Gowers GF, Bell DJ, Öling D, Larsson N, Wigglesworth M, Ladds G, Ellis T. Shaw WM, et al. Among authors: wigglesworth m. Cell. 2019 Apr 18;177(3):782-796.e27. doi: 10.1016/j.cell.2019.02.023. Epub 2019 Apr 4. Cell. 2019. PMID: 30955892 Free PMC article.
Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors.
Southern C, Cook JM, Neetoo-Isseljee Z, Taylor DL, Kettleborough CA, Merritt A, Bassoni DL, Raab WJ, Quinn E, Wehrman TS, Davenport AP, Brown AJ, Green A, Wigglesworth MJ, Rees S. Southern C, et al. Among authors: wigglesworth mj. J Biomol Screen. 2013 Jun;18(5):599-609. doi: 10.1177/1087057113475480. Epub 2013 Feb 8. J Biomol Screen. 2013. PMID: 23396314
High-Throughput Cell Toxicity Assays.
Murray D, McWilliams L, Wigglesworth M. Murray D, et al. Among authors: wigglesworth m. Methods Mol Biol. 2016;1439:245-62. doi: 10.1007/978-1-4939-3673-1_16. Methods Mol Biol. 2016. PMID: 27317000
The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.
Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ. Brown AJ, et al. Among authors: wigglesworth mj. J Biol Chem. 2003 Mar 28;278(13):11312-9. doi: 10.1074/jbc.M211609200. Epub 2002 Dec 19. J Biol Chem. 2003. PMID: 12496283 Free article.
43 results