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The benefits, limitations and opportunities of preclinical models for neonatal drug development.
Campion S, Inselman A, Hayes B, Casiraghi C, Joseph D, Facchinetti F, Salomone F, Schmitt G, Hui J, Davis-Bruno K, Van Malderen K, Morford L, De Schaepdrijver L, Wiesner L, Kourula S, Seo S, Laffan S, Urmaliya V, Chen C. Campion S, et al. Among authors: wiesner l. Dis Model Mech. 2022 Apr 1;15(4):dmm049065. doi: 10.1242/dmm.049065. Epub 2022 Apr 25. Dis Model Mech. 2022. PMID: 35466995 Free PMC article. Review.
Birth Control in Clinical Trials: Industry Survey of Current Use Practices, Governance, and Monitoring.
Stewart J, Breslin WJ, Beyer BK, Chadwick K, De Schaepdrijver L, Desai M, Enright B, Foster W, Hui JY, Moffat GJ, Tornesi B, Van Malderen K, Wiesner L, Chen CL. Stewart J, et al. Among authors: wiesner l. Ther Innov Regul Sci. 2016 Mar;50(2):155-168. doi: 10.1177/2168479015608415. Epub 2015 Oct 8. Ther Innov Regul Sci. 2016. PMID: 27042398 Free PMC article.
A study protocol to characterise pathophysiological and molecular markers of rheumatic heart disease and degenerative aortic stenosis using multiparametric cardiovascular imaging and multiomics techniques.
Mutithu DW, Aremu OO, Mokaila D, Bana T, Familusi M, Taylor L, Martin LJ, Heathfield LJ, Kirwan JA, Wiesner L, Adeola HA, Lumngwena EN, Manganyi R, Skatulla S, Naidoo R, Ntusi NAB. Mutithu DW, et al. Among authors: wiesner l. PLoS One. 2024 May 13;19(5):e0303496. doi: 10.1371/journal.pone.0303496. eCollection 2024. PLoS One. 2024. PMID: 38739622 Free PMC article.
High-Dose Isoniazid Lacks EARLY Bactericidal Activity Against Isoniazid-resistant Tuberculosis Mediated by katG Mutations: A Randomized, Phase 2 Clinical Trial.
Gausi K, Ignatius EH, De Jager V, Upton C, Kim S, McKhann A, Moran L, Wiesner L, von Groote-Bidlingmaier F, Marzinek P, Vanker N, Yvetot J, Pierre S, Rosenkranz SL, Swindells S, Diacon AH, Nuermberger EL, Denti P, Dooley KE; A5312 Study Team. Gausi K, et al. Among authors: wiesner l. Am J Respir Crit Care Med. 2024 Apr 2. doi: 10.1164/rccm.202311-2004OC. Online ahead of print. Am J Respir Crit Care Med. 2024. PMID: 38564365
Molecular docking, molecular dynamics simulations and binding free energy studies of interactions between Mycobacterium tuberculosis Pks13, PknG and bioactive constituents of extremophilic bacteria.
Nyambo K, Tapfuma KI, Adu-Amankwaah F, Julius L, Baatjies L, Niang IS, Smith L, Govender KK, Ngxande M, Watson DJ, Wiesner L, Mavumengwana V. Nyambo K, et al. Among authors: wiesner l. Sci Rep. 2024 Mar 21;14(1):6794. doi: 10.1038/s41598-024-57124-9. Sci Rep. 2024. PMID: 38514663 Free PMC article.
Relationship Between Tenofovir Diphosphate Concentrations in Dried Blood Spots and Virological Outcomes After Initiating Tenofovir-Lamivudine-Dolutegravir as First-Line or Second-Line Antiretroviral Therapy.
van Heerden JK, Meintjes G, Barr D, Zhao Y, Griesel R, Keene CM, Wiesner L, Galileya LT, Denti P, Maartens G. van Heerden JK, et al. Among authors: wiesner l. J Acquir Immune Defic Syndr. 2024 Mar 1;95(3):260-267. doi: 10.1097/QAI.0000000000003341. J Acquir Immune Defic Syndr. 2024. PMID: 38408216 Free PMC article.
305 results