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Myeloid PHD2 deficiency accelerates neointima formation via Hif-1α.
Christoph M, Pfluecke C, Mensch M, Augstein A, Jellinghaus S, Ende G, Mierke J, Franke K, Wielockx B, Ibrahim K, Poitz DM. Christoph M, et al. Among authors: wielockx b. Mol Immunol. 2022 Sep;149:48-58. doi: 10.1016/j.molimm.2022.06.003. Epub 2022 Jun 17. Mol Immunol. 2022. PMID: 35724581
HIF in vascular development and tumour angiogenesis.
Breier G, Licht AH, Nicolaus A, Klotzsche A, Wielockx B, Kirsnerova Z. Breier G, et al. Among authors: wielockx b. Novartis Found Symp. 2007;283:126-33; discussion 133-8, 238-41. doi: 10.1002/9780470319413.ch10. Novartis Found Symp. 2007. PMID: 18300418
Hypoxia-mediated regulation of stem cell fate.
Singh RP, Franke K, Wielockx B. Singh RP, et al. Among authors: wielockx b. High Alt Med Biol. 2012 Sep;13(3):162-8. doi: 10.1089/ham.2012.1043. High Alt Med Biol. 2012. PMID: 22994515 Review.
HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.
Franke K, Kalucka J, Mamlouk S, Singh RP, Muschter A, Weidemann A, Iyengar V, Jahn S, Wieczorek K, Geiger K, Muders M, Sykes AM, Poitz DM, Ripich T, Otto T, Bergmann S, Breier G, Baretton G, Fong GH, Greaves DR, Bornstein S, Chavakis T, Fandrey J, Gassmann M, Wielockx B. Franke K, et al. Among authors: wielockx b. Blood. 2013 Feb 21;121(8):1436-45. doi: 10.1182/blood-2012-08-449181. Epub 2012 Dec 20. Blood. 2013. PMID: 23264599 Free PMC article.
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
Singh RP, Franke K, Kalucka J, Mamlouk S, Muschter A, Gembarska A, Grinenko T, Willam C, Naumann R, Anastassiadis K, Stewart AF, Bornstein S, Chavakis T, Breier G, Waskow C, Wielockx B. Singh RP, et al. Among authors: wielockx b. Blood. 2013 Jun 27;121(26):5158-66. doi: 10.1182/blood-2012-12-471185. Epub 2013 May 10. Blood. 2013. PMID: 23667053 Free article.
Erythrocytosis: the HIF pathway in control.
Franke K, Gassmann M, Wielockx B. Franke K, et al. Among authors: wielockx b. Blood. 2013 Aug 15;122(7):1122-8. doi: 10.1182/blood-2013-01-478065. Epub 2013 Jun 3. Blood. 2013. PMID: 23733342 Free article. Review.
PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.
Klotzsche-von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, Flamme I, Wielockx B, Breier G. Klotzsche-von Ameln A, et al. Among authors: wielockx b. Mol Cancer Res. 2013 Nov;11(11):1337-48. doi: 10.1158/1541-7786.MCR-13-0201. Epub 2013 Sep 18. Mol Cancer Res. 2013. PMID: 24048703
90 results