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Page 1
Utility of the RIG-I Agonist Triphosphate RNA for Melanoma Therapy.
Helms MW, Jahn-Hofmann K, Gnerlich F, Metz-Weidmann C, Braun M, Dietert G, Scherer P, Grandien K, Theilhaber J, Cao H, Wagenaar TR, Schnurr MM, Endres S, Wiederschain D, Scheidler S, Rothenfußer S, Brunner B, König LM. Helms MW, et al. Among authors: wiederschain d. Mol Cancer Ther. 2019 Dec;18(12):2343-2356. doi: 10.1158/1535-7163.MCT-18-1262. Epub 2019 Sep 12. Mol Cancer Ther. 2019. PMID: 31515294
Anti-miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation.
Wagenaar TR, Zabludoff S, Ahn SM, Allerson C, Arlt H, Baffa R, Cao H, Davis S, Garcia-Echeverria C, Gaur R, Huang SM, Jiang L, Kim D, Metz-Weidmann C, Pavlicek A, Pollard J, Reeves J, Rocnik JL, Scheidler S, Shi C, Sun F, Tolstykh T, Weber W, Winter C, Yu E, Yu Q, Zheng G, Wiederschain D. Wagenaar TR, et al. Among authors: wiederschain d. Mol Cancer Res. 2015 Jun;13(6):1009-21. doi: 10.1158/1541-7786.MCR-14-0703. Epub 2015 Mar 10. Mol Cancer Res. 2015. PMID: 25758165
Oncogenic dependency on β-catenin in liver cancer cell lines correlates with pathway activation.
Ding Z, Shi C, Jiang L, Tolstykh T, Cao H, Bangari DS, Ryan S, Levit M, Jin T, Mamaat K, Yu Q, Qu H, Hopke J, Cindhuchao M, Hoffmann D, Sun F, Helms MW, Jahn-Hofmann K, Scheidler S, Schweizer L, Fang DD, Pollard J, Winter C, Wiederschain D. Ding Z, et al. Among authors: wiederschain d. Oncotarget. 2017 Sep 28;8(70):114526-114539. doi: 10.18632/oncotarget.21298. eCollection 2017 Dec 29. Oncotarget. 2017. PMID: 29383099 Free PMC article.
An experimental model of anti-PD-1 resistance exhibits activation of TGFß and Notch pathways and is sensitive to local mRNA immunotherapy.
Bernardo M, Tolstykh T, Zhang YA, Bangari DS, Cao H, Heyl KA, Lee JS, Malkova NV, Malley K, Marquez E, Pollard J, Qu H, Roberts E, Ryan S, Singh K, Sun F, Wang E, Bahjat K, Wiederschain D, Wagenaar TR. Bernardo M, et al. Among authors: wiederschain d. Oncoimmunology. 2021 Mar 16;10(1):1881268. doi: 10.1080/2162402X.2021.1881268. Oncoimmunology. 2021. PMID: 33796402 Free PMC article.
Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models.
Hotz C, Wagenaar TR, Gieseke F, Bangari DS, Callahan M, Cao H, Diekmann J, Diken M, Grunwitz C, Hebert A, Hsu K, Bernardo M, Karikó K, Kreiter S, Kuhn AN, Levit M, Malkova N, Masciari S, Pollard J, Qu H, Ryan S, Selmi A, Schlereth J, Singh K, Sun F, Tillmann B, Tolstykh T, Weber W, Wicke L, Witzel S, Yu Q, Zhang YA, Zheng G, Lager J, Nabel GJ, Sahin U, Wiederschain D. Hotz C, et al. Among authors: wiederschain d. Sci Transl Med. 2021 Sep 8;13(610):eabc7804. doi: 10.1126/scitranslmed.abc7804. Epub 2021 Sep 8. Sci Transl Med. 2021. PMID: 34516826
Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells.
Wagenaar TR, Tolstykh T, Shi C, Jiang L, Zhang J, Li Z, Yu Q, Qu H, Sun F, Cao H, Pollard J, Dai S, Gao Q, Zhang B, Arlt H, Cindhuchao M, Hoffmann D, Light M, Jensen K, Hopke J, Newcombe R, Garcia-Echeverria C, Winter C, Zabludoff S, Wiederschain D. Wagenaar TR, et al. Among authors: wiederschain d. Nucleic Acids Res. 2015 Jan;43(2):1204-15. doi: 10.1093/nar/gku1367. Epub 2014 Dec 30. Nucleic Acids Res. 2015. PMID: 25550434 Free PMC article.
Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade.
Greco R, Qu H, Qu H, Theilhaber J, Shapiro G, Gregory R, Winter C, Malkova N, Sun F, Jaworski J, Best A, Pao L, Hebert A, Levit M, Protopopov A, Pollard J, Bahjat K, Wiederschain D, Sharma S. Greco R, et al. Among authors: wiederschain d. Oncoimmunology. 2020 Sep 13;9(1):1811605. doi: 10.1080/2162402X.2020.1811605. Oncoimmunology. 2020. PMID: 33224628 Free PMC article.
Isatuximab Acts Through Fc-Dependent, Independent, and Direct Pathways to Kill Multiple Myeloma Cells.
Zhu C, Song Z, Wang A, Srinivasan S, Yang G, Greco R, Theilhaber J, Shehu E, Wu L, Yang ZY, Passe-Coutrin W, Fournier A, Tai YT, Anderson KC, Wiederschain D, Bahjat K, Adrián FJ, Chiron M. Zhu C, et al. Among authors: wiederschain d. Front Immunol. 2020 Aug 14;11:1771. doi: 10.3389/fimmu.2020.01771. eCollection 2020. Front Immunol. 2020. PMID: 32922390 Free PMC article.
BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression.
Mandel I, Haves Ziv D, Goldshtein I, Peretz T, Alishekevitz D, Fridman Dror A, Hakim M, Hashmueli S, Friedman I, Sapir Y, Greco R, Qu H, Nestle F, Wiederschain D, Pao L, Sharma S, Ben Moshe T. Mandel I, et al. Among authors: wiederschain d. J Immunother Cancer. 2022 Sep;10(9):e004859. doi: 10.1136/jitc-2022-004859. J Immunother Cancer. 2022. PMID: 36096532 Free PMC article.
Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.
Tateishi K, Wakimoto H, Iafrate AJ, Tanaka S, Loebel F, Lelic N, Wiederschain D, Bedel O, Deng G, Zhang B, He T, Shi X, Gerszten RE, Zhang Y, Yeh JJ, Curry WT, Zhao D, Sundaram S, Nigim F, Koerner MVA, Ho Q, Fisher DE, Roider EM, Kemeny LV, Samuels Y, Flaherty KT, Batchelor TT, Chi AS, Cahill DP. Tateishi K, et al. Among authors: wiederschain d. Cancer Cell. 2015 Dec 14;28(6):773-784. doi: 10.1016/j.ccell.2015.11.006. Cancer Cell. 2015. PMID: 26678339 Free PMC article.
54 results