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Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Rao SPS, Gould MK, Noeske J, Saldivia M, Jumani RS, Ng PS, René O, Chen YL, Kaiser M, Ritchie R, Francisco AF, Johnson N, Patra D, Cheung H, Deniston C, Schenk AD, Cortopassi WA, Schmidt RS, Wiedemar N, Thomas B, Palkar R, Ghafar NA, Manoharan V, Luu C, Gable JE, Wan KF, Myburgh E, Mottram JC, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly JM, Manjunatha UH, Mäser P, Jiricek J, Lakshminarayana SB, Barrett MP, Diagana TT. Rao SPS, et al. Among authors: wiedemar n. Science. 2023 Jun 30;380(6652):1349-1356. doi: 10.1126/science.adh0614. Epub 2023 Jun 29. Science. 2023. PMID: 37384702 Free article.
100 Years of Suramin.
Wiedemar N, Hauser DA, Mäser P. Wiedemar N, et al. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01168-19. doi: 10.1128/AAC.01168-19. Print 2020 Feb 21. Antimicrob Agents Chemother. 2020. PMID: 31844000 Free PMC article. Review.
Structure of trypanosome coat protein VSGsur and function in suramin resistance.
Zeelen J, van Straaten M, Verdi J, Hempelmann A, Hashemi H, Perez K, Jeffrey PD, Hälg S, Wiedemar N, Mäser P, Papavasiliou FN, Stebbins CE. Zeelen J, et al. Among authors: wiedemar n. Nat Microbiol. 2021 Mar;6(3):392-400. doi: 10.1038/s41564-020-00844-1. Epub 2021 Jan 18. Nat Microbiol. 2021. PMID: 33462435 Free PMC article.
Suramin action in African trypanosomes involves a RuvB-like DNA helicase.
Albisetti A, Hälg S, Zoltner M, Mäser P, Wiedemar N. Albisetti A, et al. Among authors: wiedemar n. Int J Parasitol Drugs Drug Resist. 2023 Dec;23:44-53. doi: 10.1016/j.ijpddr.2023.09.003. Epub 2023 Sep 19. Int J Parasitol Drugs Drug Resist. 2023. PMID: 37757728 Free PMC article.
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation.
Bopp S, Pasaje CFA, Summers RL, Magistrado-Coxen P, Schindler KA, Corpas-Lopez V, Yeo T, Mok S, Dey S, Smick S, Nasamu AS, Demas AR, Milne R, Wiedemar N, Corey V, Gomez-Lorenzo MG, Franco V, Early AM, Lukens AK, Milner D, Furtado J, Gamo FJ, Winzeler EA, Volkman SK, Duffey M, Laleu B, Fidock DA, Wyllie S, Niles JC, Wirth DF. Bopp S, et al. Among authors: wiedemar n. Nat Commun. 2023 Mar 16;14(1):1455. doi: 10.1038/s41467-023-36921-2. Nat Commun. 2023. PMID: 36927839 Free PMC article.
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