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Esketamine inhaled as dry powder: Pharmacokinetic, pharmacodynamic and safety assessment in a preclinical study.
Matłoka M, Janowska S, Gajos-Draus A, Ziółkowski H, Janicka M, Perko P, Kamil K, Pankiewicz P, Moszczyński-Pętkowski R, Mach M, Dera P, Abramski K, Teska-Kamińska M, Tratkiewicz E, Wieczorek M, Pieczykolan J. Matłoka M, et al. Among authors: wieczorek m. Pulm Pharmacol Ther. 2022 Jun;73-74:102127. doi: 10.1016/j.pupt.2022.102127. Epub 2022 Apr 14. Pulm Pharmacol Ther. 2022. PMID: 35429651
Synthesis and characterization of novel classes of PDE10A inhibitors - 1H-1,3-benzodiazoles and imidazo[1,2-a]pyrimidines.
Moszczyński-Pętkowski R, Majer J, Borkowska M, Bojarski Ł, Janowska S, Matłoka M, Stefaniak F, Smuga D, Bazydło K, Dubiel K, Wieczorek M. Moszczyński-Pętkowski R, et al. Among authors: wieczorek m. Eur J Med Chem. 2018 Jul 15;155:96-116. doi: 10.1016/j.ejmech.2018.05.043. Epub 2018 May 30. Eur J Med Chem. 2018. PMID: 29870883
2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design.
Hogendorf AS, Hogendorf A, Kurczab R, Kalinowska-Tłuścik J, Popik P, Nikiforuk A, Krawczyk M, Satała G, Lenda T, Knutelska J, Bugno R, Staroń J, Pietruś W, Matłoka M, Dubiel K, Moszczyński-Pętkowski R, Pieczykolan J, Wieczorek M, Pilarski B, Zajdel P, Bojarski AJ. Hogendorf AS, et al. Among authors: wieczorek m. Eur J Med Chem. 2019 Oct 1;179:1-15. doi: 10.1016/j.ejmech.2019.06.001. Epub 2019 Jun 5. Eur J Med Chem. 2019. PMID: 31229883
Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties.
Staroń J, Kurczab R, Warszycki D, Satała G, Krawczyk M, Bugno R, Lenda T, Popik P, Hogendorf AS, Hogendorf A, Dubiel K, Matłoka M, Moszczyński-Pętkowski R, Pieczykolan J, Wieczorek M, Zajdel P, Bojarski AJ. Staroń J, et al. Among authors: wieczorek m. Eur J Med Chem. 2020 Jan 1;185:111857. doi: 10.1016/j.ejmech.2019.111857. Epub 2019 Nov 7. Eur J Med Chem. 2020. PMID: 31734022 Free article.
Preclinical characterization of CPL302-253, a selective inhibitor of PI3Kδ, as the candidate for the inhalatory treatment and prevention of Asthma.
Gunerka P, Gala K, Banach M, Dominowski J, Hucz-Kalitowska J, Mulewski K, Hajnal A, Mikus EG, Smuga D, Zagozda M, Dubiel K, Pieczykolan J, Zygmunt BM, Wieczorek M. Gunerka P, et al. Among authors: wieczorek m. PLoS One. 2020 Jul 23;15(7):e0236159. doi: 10.1371/journal.pone.0236159. eCollection 2020. PLoS One. 2020. PMID: 32702053 Free PMC article.
Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil.
Sikora J, Podsiedlik M, Pietras T, Kosmalski M, Matłoka M, Moszczyński-Petkowski R, Wieczorek M, Markowicz-Piasecka M. Sikora J, et al. Among authors: wieczorek m. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1743-1750. doi: 10.1080/14756366.2020.1818739. J Enzyme Inhib Med Chem. 2020. PMID: 32938236 Free PMC article.
Discovery and optimization of novel pyrazole-benzimidazole CPL304110, as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3).
Yamani A, Zdżalik-Bielecka D, Lipner J, Stańczak A, Piórkowska N, Stańczak PS, Olejkowska P, Hucz-Kalitowska J, Magdycz M, Dzwonek K, Dubiel K, Lamparska-Przybysz M, Popiel D, Pieczykolan J, Wieczorek M. Yamani A, et al. Among authors: wieczorek m. Eur J Med Chem. 2021 Jan 15;210:112990. doi: 10.1016/j.ejmech.2020.112990. Epub 2020 Nov 7. Eur J Med Chem. 2021. PMID: 33199155 Review.
A novel JAK/ROCK inhibitor, CPL409116, demonstrates potent efficacy in the mouse model of systemic lupus erythematosus.
Dulak-Lis M, Bujak A, Gala K, Banach M, Kędzierska U, Miszkiel J, Hucz-Kalitowska J, Mroczkiewicz M, Stypik B, Szymczak K, Gunerka P, Dubiel K, Zygmunt BM, Wieczorek M, Pieczykolan JS. Dulak-Lis M, et al. Among authors: wieczorek m. J Pharmacol Sci. 2021 Apr;145(4):340-348. doi: 10.1016/j.jphs.2021.02.002. Epub 2021 Feb 9. J Pharmacol Sci. 2021. PMID: 33712286 Free article.
Development and Bio-Predictive Evaluation of Biopharmaceutical Properties of Sustained-Release Tablets with a Novel GPR40 Agonist for a First-in-Human Clinical Trial.
Juszczyk E, Kisło K, Żero P, Tratkiewicz E, Wieczorek M, Paszkowska J, Banach G, Wiater M, Hoc D, Garbacz G, Sczodrok J, Danielak D. Juszczyk E, et al. Among authors: wieczorek m. Pharmaceutics. 2021 May 28;13(6):804. doi: 10.3390/pharmaceutics13060804. Pharmaceutics. 2021. PMID: 34071286 Free PMC article.
554 results