Widrick JJ - Search Results

1

Directed evolution of a family of AAV capsid variants enabling potent muscle-directed gene delivery across species.

Tabebordbar M, Lagerborg KA, Stanton A, King EM, Ye S, Tellez L, Krunnfusz A, Tavakoli S, Widrick JJ, Messemer KA, Troiano EC, Moghadaszadeh B, Peacker BL, Leacock KA, Horwitz N, Beggs AH, Wagers AJ, Sabeti PC. Tabebordbar M, et al. Among authors: widrick jj. Cell. 2021 Sep 16;184(19):4919-4938.e22. doi: 10.1016/j.cell.2021.08.028. Epub 2021 Sep 9. Cell. 2021. PMID: 34506722 Free PMC article.

2

Enzyme replacement therapy rescues weakness and improves muscle pathology in mice with X-linked myotubular myopathy.

Lawlor MW, Armstrong D, Viola MG, Widrick JJ, Meng H, Grange RW, Childers MK, Hsu CP, O'Callaghan M, Pierson CR, Buj-Bello A, Beggs AH. Lawlor MW, et al. Among authors: widrick jj. Hum Mol Genet. 2013 Apr 15;22(8):1525-38. doi: 10.1093/hmg/ddt003. Epub 2013 Jan 9. Hum Mol Genet. 2013. PMID: 23307925 Free PMC article.

3

In vivo gene editing in dystrophic mouse muscle and muscle stem cells.

Tabebordbar M, Zhu K, Cheng JKW, Chew WL, Widrick JJ, Yan WX, Maesner C, Wu EY, Xiao R, Ran FA, Cong L, Zhang F, Vandenberghe LH, Church GM, Wagers AJ. Tabebordbar M, et al. Among authors: widrick jj. Science. 2016 Jan 22;351(6271):407-411. doi: 10.1126/science.aad5177. Epub 2015 Dec 31. Science. 2016. PMID: 26721686 Free PMC article.

4

Muscle dysfunction in a zebrafish model of Duchenne muscular dystrophy.

Widrick JJ, Alexander MS, Sanchez B, Gibbs DE, Kawahara G, Beggs AH, Kunkel LM. Widrick JJ, et al. Physiol Genomics. 2016 Nov 1;48(11):850-860. doi: 10.1152/physiolgenomics.00088.2016. Epub 2016 Oct 7. Physiol Genomics. 2016. PMID: 27764767 Free PMC article.

5

SPEG-deficient skeletal muscles exhibit abnormal triad and defective calcium handling.

Huntoon V, Widrick JJ, Sanchez C, Rosen SM, Kutchukian C, Cao S, Pierson CR, Liu X, Perrella MA, Beggs AH, Jacquemond V, Agrawal PB. Huntoon V, et al. Among authors: widrick jj. Hum Mol Genet. 2018 May 1;27(9):1608-1617. doi: 10.1093/hmg/ddy068. Hum Mol Genet. 2018. PMID: 29474540 Free PMC article.

6

RNA helicase, DDX27 regulates skeletal muscle growth and regeneration by modulation of translational processes.

Bennett AH, O'Donohue MF, Gundry SR, Chan AT, Widrick J, Draper I, Chakraborty A, Zhou Y, Zon LI, Gleizes PE, Beggs AH, Gupta VA. Bennett AH, et al. PLoS Genet. 2018 Mar 8;14(3):e1007226. doi: 10.1371/journal.pgen.1007226. eCollection 2018 Mar. PLoS Genet. 2018. PMID: 29518074 Free PMC article.

7

An open source microcontroller based flume for evaluating swimming performance of larval, juvenile, and adult zebrafish.

Widrick JJ, Gibbs DE, Sanchez B, Gupta VA, Pakula A, Lawrence C, Beggs AH, Kunkel LM. Widrick JJ, et al. PLoS One. 2018 Jun 26;13(6):e0199712. doi: 10.1371/journal.pone.0199712. eCollection 2018. PLoS One. 2018. PMID: 29944715 Free PMC article.

8

Discovery of Novel Therapeutics for Muscular Dystrophies using Zebrafish Phenotypic Screens.

Widrick JJ, Kawahara G, Alexander MS, Beggs AH, Kunkel LM. Widrick JJ, et al. J Neuromuscul Dis. 2019;6(3):271-287. doi: 10.3233/JND-190389. J Neuromuscul Dis. 2019. PMID: 31282429 Free PMC article. Review.

9

Optimizing assays of zebrafish larvae swimming performance for drug discovery.

Widrick JJ, Lambert MR, Kunkel LM, Beggs AH. Widrick JJ, et al. Expert Opin Drug Discov. 2023 Jun;18(6):629-641. doi: 10.1080/17460441.2023.2211802. Epub 2023 May 15. Expert Opin Drug Discov. 2023. PMID: 37183669 Review.

10

PDE10A Inhibition Reduces the Manifestation of Pathology in DMD Zebrafish and Represses the Genetic Modifier PITPNA.

Lambert MR, Spinazzola JM, Widrick JJ, Pakula A, Conner JR, Chin JE, Owens JM, Kunkel LM. Lambert MR, et al. Among authors: widrick jj. Mol Ther. 2021 Mar 3;29(3):1086-1101. doi: 10.1016/j.ymthe.2020.11.021. Epub 2020 Nov 20. Mol Ther. 2021. PMID: 33221436 Free PMC article.

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