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Page 1
In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus.
Vugmeyster Y, Guay H, Szklut P, Qian MD, Jin M, Widom A, Spaulding V, Bennett F, Lowe L, Andreyeva T, Lowe D, Lane S, Thom G, Valge-Archer V, Gill D, Young D, Bloom L. Vugmeyster Y, et al. Among authors: widom a. MAbs. 2010 May-Jun;2(3):335-46. doi: 10.4161/mabs.2.3.11850. Epub 2010 May 23. MAbs. 2010. PMID: 20424514 Free PMC article.
Interleukin-13 neutralization by two distinct receptor blocking mechanisms reduces immunoglobulin E responses and lung inflammation in cynomolgus monkeys.
Kasaian MT, Tan XY, Jin M, Fitz L, Marquette K, Wood N, Cook TA, Lee J, Widom A, Agostinelli R, Bree A, Schlerman FJ, Olland S, Wadanoli M, Sypek J, Gill D, Goldman SJ, Tchistiakova L. Kasaian MT, et al. Among authors: widom a. J Pharmacol Exp Ther. 2008 Jun;325(3):882-92. doi: 10.1124/jpet.108.136515. Epub 2008 Mar 12. J Pharmacol Exp Ther. 2008. PMID: 18337474
Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
Basi GS, Feinberg H, Oshidari F, Anderson J, Barbour R, Baker J, Comery TA, Diep L, Gill D, Johnson-Wood K, Goel A, Grantcharova K, Lee M, Li J, Partridge A, Griswold-Prenner I, Piot N, Walker D, Widom A, Pangalos MN, Seubert P, Jacobsen JS, Schenk D, Weis WI. Basi GS, et al. Among authors: widom a. J Biol Chem. 2010 Jan 29;285(5):3417-27. doi: 10.1074/jbc.M109.045187. Epub 2009 Nov 18. J Biol Chem. 2010. PMID: 19923222 Free PMC article.
Efficacy of IL-13 neutralization in a sheep model of experimental asthma.
Kasaian MT, Donaldson DD, Tchistiakova L, Marquette K, Tan XY, Ahmed A, Jacobson BA, Widom A, Cook TA, Xu X, Barry AB, Goldman SJ, Abraham WM. Kasaian MT, et al. Among authors: widom a. Am J Respir Cell Mol Biol. 2007 Mar;36(3):368-76. doi: 10.1165/rcmb.2006-0244OC. Epub 2006 Oct 5. Am J Respir Cell Mol Biol. 2007. PMID: 17023688
IL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeys.
Bree A, Schlerman FJ, Wadanoli M, Tchistiakova L, Marquette K, Tan XY, Jacobson BA, Widom A, Cook TA, Wood N, Vunnum S, Krykbaev R, Xu X, Donaldson DD, Goldman SJ, Sypek J, Kasaian MT. Bree A, et al. Among authors: widom a. J Allergy Clin Immunol. 2007 May;119(5):1251-7. doi: 10.1016/j.jaci.2007.02.009. Epub 2007 Mar 26. J Allergy Clin Immunol. 2007. PMID: 17379289
Inhibition of myostatin in adult mice increases skeletal muscle mass and strength.
Whittemore LA, Song K, Li X, Aghajanian J, Davies M, Girgenrath S, Hill JJ, Jalenak M, Kelley P, Knight A, Maylor R, O'Hara D, Pearson A, Quazi A, Ryerson S, Tan XY, Tomkinson KN, Veldman GM, Widom A, Wright JF, Wudyka S, Zhao L, Wolfman NM. Whittemore LA, et al. Among authors: widom a. Biochem Biophys Res Commun. 2003 Jan 24;300(4):965-71. doi: 10.1016/s0006-291x(02)02953-4. Biochem Biophys Res Commun. 2003. PMID: 12559968
Kinetic analysis of a high-affinity antibody/antigen interaction performed by multiple Biacore users.
Katsamba PS, Navratilova I, Calderon-Cacia M, Fan L, Thornton K, Zhu M, Bos TV, Forte C, Friend D, Laird-Offringa I, Tavares G, Whatley J, Shi E, Widom A, Lindquist KC, Klakamp S, Drake A, Bohmann D, Roell M, Rose L, Dorocke J, Roth B, Luginbühl B, Myszka DG. Katsamba PS, et al. Among authors: widom a. Anal Biochem. 2006 May 15;352(2):208-21. doi: 10.1016/j.ab.2006.01.034. Epub 2006 Feb 23. Anal Biochem. 2006. PMID: 16564019
49 results