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Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Nat Chem. 2022 Jan;14(1):15-24. doi: 10.1038/s41557-021-00831-x. Epub 2021 Dec 13.
Nat Chem. 2022.
PMID: 34903857
Profiling interactions of vaborbactam with metallo-β-lactamases.
Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J.
Langley GW, et al. Among authors: widlake e.
Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17.
Bioorg Med Chem Lett. 2019.
PMID: 31171422
Free PMC article.
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Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases.
Krajnc A, Brem J, Hinchliffe P, Calvopiña K, Panduwawala TD, Lang PA, Kamps JJAG, Tyrrell JM, Widlake E, Saward BG, Walsh TR, Spencer J, Schofield CJ.
Krajnc A, et al. Among authors: widlake e.
J Med Chem. 2019 Sep 26;62(18):8544-8556. doi: 10.1021/acs.jmedchem.9b00911. Epub 2019 Sep 16.
J Med Chem. 2019.
PMID: 31454231
Free PMC article.
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In vitro efficacy of imipenem-relebactam and cefepime-AAI101 against a global collection of ESBL-positive and carbapenemase-producing Enterobacteriaceae.
Tselepis L, Langley GW, Aboklaish AF, Widlake E, Jackson DE, Walsh TR, Schofield CJ, Brem J, Tyrrell JM.
Tselepis L, et al. Among authors: widlake e.
Int J Antimicrob Agents. 2020 Jul;56(1):105925. doi: 10.1016/j.ijantimicag.2020.105925. Epub 2020 Feb 18.
Int J Antimicrob Agents. 2020.
PMID: 32084512
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In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii.
Juhas M, Widlake E, Teo J, Huseby DL, Tyrrell JM, Polikanov YS, Ercan O, Petersson A, Cao S, Aboklaish AF, Rominski A, Crich D, Böttger EC, Walsh TR, Hughes D, Hobbie SN.
Juhas M, et al. Among authors: widlake e.
J Antimicrob Chemother. 2019 Apr 1;74(4):944-952. doi: 10.1093/jac/dky546.
J Antimicrob Chemother. 2019.
PMID: 30629184
Free PMC article.
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Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial.
Muers MF, Stephens RJ, Fisher P, Darlison L, Higgs CM, Lowry E, Nicholson AG, O'Brien M, Peake M, Rudd R, Snee M, Steele J, Girling DJ, Nankivell M, Pugh C, Parmar MK; MS01 Trial Management Group.
Muers MF, et al.
Lancet. 2008 May 17;371(9625):1685-94. doi: 10.1016/S0140-6736(08)60727-8.
Lancet. 2008.
PMID: 18486741
Free PMC article.
Clinical Trial.
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