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Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.
Divakaran A, Talluri SK, Ayoub AM, Mishra NK, Cui H, Widen JC, Berndt N, Zhu JY, Carlson AS, Topczewski JJ, Schonbrunn EK, Harki DA, Pomerantz WCK. Divakaran A, et al. Among authors: widen jc. J Med Chem. 2018 Oct 25;61(20):9316-9334. doi: 10.1021/acs.jmedchem.8b01248. Epub 2018 Oct 16. J Med Chem. 2018. PMID: 30253095 Free PMC article.
Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.
Kempema AM, Widen JC, Hexum JK, Andrews TE, Wang D, Rathe SK, Meece FA, Noble KE, Sachs Z, Largaespada DA, Harki DA. Kempema AM, et al. Among authors: widen jc. Bioorg Med Chem. 2015 Aug 1;23(15):4737-4745. doi: 10.1016/j.bmc.2015.05.037. Epub 2015 May 30. Bioorg Med Chem. 2015. PMID: 26088334 Free PMC article.
A redox economical synthesis of bioactive 6,12-guaianolides.
Wen B, Hexum JK, Widen JC, Harki DA, Brummond KM. Wen B, et al. Among authors: widen jc. Org Lett. 2013 Jun 7;15(11):2644-7. doi: 10.1021/ol400904y. Epub 2013 May 10. Org Lett. 2013. PMID: 23662902 Free PMC article.
16 results