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Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome.
Pharmaceuticals (Basel). 2010 Jun 4;3(6):1842-1872. doi: 10.3390/ph3061842.
Pharmaceuticals (Basel). 2010.
PMID: 27713332
Free PMC article.
Review.
Synthesis and in vivo activity of MK2 and MK2 substrate-selective p38alpha(MAPK) inhibitors in Werner syndrome cells.
Davis T, Bagley MC, Dix MC, Murziani PG, Rokicki MJ, Widdowson CS, Zayed JM, Bachler MA, Kipling D.
Davis T, et al. Among authors: widdowson cs.
Bioorg Med Chem Lett. 2007 Dec 15;17(24):6832-5. doi: 10.1016/j.bmcl.2007.10.036. Epub 2007 Oct 17.
Bioorg Med Chem Lett. 2007.
PMID: 17964780
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Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome.
Bagley MC, Davis T, Rokicki MJ, Widdowson CS, Kipling D.
Bagley MC, et al. Among authors: widdowson cs.
Future Med Chem. 2010 Feb;2(2):193-201. doi: 10.4155/fmc.09.163.
Future Med Chem. 2010.
PMID: 21426186
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Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors.
Davis T, Dix MC, Rokicki MJ, Brook AJ, Widdowson CS, Kipling D, Bagley MC.
Davis T, et al. Among authors: widdowson cs.
Chem Cent J. 2011 Dec 8;5(1):83. doi: 10.1186/1752-153X-5-83.
Chem Cent J. 2011.
PMID: 22152108
Free PMC article.
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Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing.
Bagley MC, Davis T, Dix MC, Widdowson CS, Kipling D.
Bagley MC, et al. Among authors: widdowson cs.
Org Biomol Chem. 2006 Nov 21;4(22):4158-64. doi: 10.1039/b611493h.
Org Biomol Chem. 2006.
PMID: 17312972
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Selective targeting of the αC and DFG-out pocket in p38 MAPK.
Röhm S, Schröder M, Dwyer JE, Widdowson CS, Chaikuad A, Berger BT, Joerger AC, Krämer A, Harbig J, Dauch D, Kudolo M, Laufer S, Bagley MC, Knapp S.
Röhm S, et al. Among authors: widdowson cs.
Eur J Med Chem. 2020 Dec 15;208:112721. doi: 10.1016/j.ejmech.2020.112721. Epub 2020 Aug 20.
Eur J Med Chem. 2020.
PMID: 33035818
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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, Ivanov D, Widdowson C, Chapman J, Lovestone S, Powell J, Proitsi P, Lupton MK, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Lynch A, Brown KS, Passmore PA, Craig D, McGuinness B, Todd S, Holmes C, Mann D, Smith AD, Beaumont H, Warden D, Wilcock G, Love S, Kehoe PG, Hooper NM, Vardy ER, Hardy J, Mead S, Fox NC, Rossor M, Collinge J, Maier W, Jessen F, Rüther E, Schürmann B, Heun R, Kölsch H, van den Bussche H, Heuser I, Kornhuber J, Wiltfang J, Dichgans M, Frölich L, Hampel H, Gallacher J, Hüll M, Rujescu D, Giegling I, Goate AM, Kauwe JS, Cruchaga C, Nowotny P, Morris JC, Mayo K, Sleegers K, Bettens K, Engelborghs S, De Deyn PP, Van Broeckhoven C, Livingston G, Bass NJ, Gurling H, McQuillin A, Gwilliam R, Deloukas P, Al-Chalabi A, Shaw CE, Tsolaki M, Singleton AB, Guerreiro R, Mühleisen TW, Nöthen MM, Moebus S, Jöckel KH, Klopp N, Wichmann HE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC; Alzheimer's Disease Neuroimaging Initiative; van Duijn CM, Breteler…
See abstract for full author list ➔
Hollingworth P, et al.
Nat Genet. 2011 May;43(5):429-35. doi: 10.1038/ng.803. Epub 2011 Apr 3.
Nat Genet. 2011.
PMID: 21460840
Free PMC article.
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