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Nitroxyl (HNO): the Cinderella of the nitric oxide story.
Irvine JC, Ritchie RH, Favaloro JL, Andrews KL, Widdop RE, Kemp-Harper BK. Irvine JC, et al. Among authors: widdop re. Trends Pharmacol Sci. 2008 Dec;29(12):601-8. doi: 10.1016/j.tips.2008.08.005. Epub 2008 Oct 1. Trends Pharmacol Sci. 2008. PMID: 18835046 Review.
Nitroxyl donors retain their depressor effects in hypertension.
Irvine JC, Ravi RM, Kemp-Harper BK, Widdop RE. Irvine JC, et al. Among authors: widdop re. Am J Physiol Heart Circ Physiol. 2013 Sep 15;305(6):H939-45. doi: 10.1152/ajpheart.00630.2012. Epub 2013 Jul 12. Am J Physiol Heart Circ Physiol. 2013. PMID: 23851276 Free PMC article.
Compound 21, a selective agonist of angiotensin AT2 receptors, prevents endothelial inflammation and leukocyte adhesion in vitro and in vivo.
Sampson AK, Irvine JC, Shihata WA, Dragoljevic D, Lumsden N, Huet O, Barnes T, Unger T, Steckelings UM, Jennings GL, Widdop RE, Chin-Dusting JP. Sampson AK, et al. Among authors: widdop re. Br J Pharmacol. 2016 Feb;173(4):729-40. doi: 10.1111/bph.13063. Epub 2015 Jun 29. Br J Pharmacol. 2016. PMID: 25560767 Free PMC article.
The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy.
Alam F, Gaspari TA, Kemp-Harper BK, Low E, Aw A, Ferens D, Spizzo I, Jefferis AM, Praveen P, Widdop RE, Bathgate RAD, Hossain MA, Samuel CS. Alam F, et al. Among authors: widdop re. Biomed Pharmacother. 2023 Apr;160:114370. doi: 10.1016/j.biopha.2023.114370. Epub 2023 Feb 6. Biomed Pharmacother. 2023. PMID: 36753958 Free article.
167 results