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Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation.
Więckowska A, Kołaczkowski M, Bucki A, Godyń J, Marcinkowska M, Więckowski K, Zaręba P, Siwek A, Kazek G, Głuch-Lutwin M, Mierzejewski P, Bienkowski P, Sienkiewicz-Jarosz H, Knez D, Wichur T, Gobec S, Malawska B. Więckowska A, et al. Among authors: wichur t. Eur J Med Chem. 2016 Nov 29;124:63-81. doi: 10.1016/j.ejmech.2016.08.016. Epub 2016 Aug 11. Eur J Med Chem. 2016. PMID: 27560283
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.
Panek D, Więckowska A, Wichur T, Bajda M, Godyń J, Jończyk J, Mika K, Janockova J, Soukup O, Knez D, Korabecny J, Gobec S, Malawska B. Panek D, et al. Among authors: wichur t. Eur J Med Chem. 2017 Jan 5;125:676-695. doi: 10.1016/j.ejmech.2016.09.078. Epub 2016 Sep 26. Eur J Med Chem. 2017. PMID: 27721153
Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents.
Panek D, Więckowska A, Jończyk J, Godyń J, Bajda M, Wichur T, Pasieka A, Knez D, Pišlar A, Korabecny J, Soukup O, Sepsova V, Sabaté R, Kos J, Gobec S, Malawska B. Panek D, et al. Among authors: wichur t. ACS Chem Neurosci. 2018 May 16;9(5):1074-1094. doi: 10.1021/acschemneuro.7b00461. Epub 2018 Feb 1. ACS Chem Neurosci. 2018. PMID: 29345897
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease.
Szałaj N, Godyń J, Jończyk J, Pasieka A, Panek D, Wichur T, Więckowski K, Zaręba P, Bajda M, Pislar A, Malawska B, Sabate R, Więckowska A. Szałaj N, et al. Among authors: wichur t. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1944-1952. doi: 10.1080/14756366.2020.1835882. J Enzyme Inhib Med Chem. 2020. PMID: 33092411 Free PMC article.
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau.
Wichur T, Pasieka A, Godyń J, Panek D, Góral I, Latacz G, Honkisz-Orzechowska E, Bucki A, Siwek A, Głuch-Lutwin M, Knez D, Brazzolotto X, Gobec S, Kołaczkowski M, Sabate R, Malawska B, Więckowska A. Wichur T, et al. Eur J Med Chem. 2021 Dec 5;225:113783. doi: 10.1016/j.ejmech.2021.113783. Epub 2021 Aug 19. Eur J Med Chem. 2021. PMID: 34461507 Free article.
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with β-amyloid anti-aggregation properties.
Wichur T, Godyń J, Góral I, Latacz G, Bucki A, Siwek A, Głuch-Lutwin M, Mordyl B, Śniecikowska J, Walczak M, Knez D, Jukič M, Sałat K, Gobec S, Kołaczkowski M, Malawska B, Brazzolotto X, Więckowska A. Wichur T, et al. Eur J Med Chem. 2021 Dec 5;225:113792. doi: 10.1016/j.ejmech.2021.113792. Epub 2021 Aug 27. Eur J Med Chem. 2021. PMID: 34530376 Free article.
12 results