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CXCL4 drives fibrosis by promoting several key cellular and molecular processes.
Affandi AJ, Carvalheiro T, Ottria A, de Haan JJ, Brans MAD, Brandt MM, Tieland RG, Lopes AP, Fernández BM, Bekker CPJ, van der Linden M, Zimmermann M, Giovannone B, Wichers CGK, Garcia S, de Kok M, Stifano G, Xu YJ, Kowalska MA, Waasdorp M, Cheng C, Gibbs S, de Jager SCA, van Roon JAG, Radstake TRDJ, Marut W. Affandi AJ, et al. Among authors: wichers cgk. Cell Rep. 2022 Jan 4;38(1):110189. doi: 10.1016/j.celrep.2021.110189. Cell Rep. 2022. PMID: 34986347 Free article.
Splenic TFH expansion participates in B-cell differentiation and antiplatelet-antibody production during immune thrombocytopenia.
Audia S, Rossato M, Santegoets K, Spijkers S, Wichers C, Bekker C, Bloem A, Boon L, Flinsenberg T, Compeer E, van den Broek T, Facy O, Ortega-Deballon P, Berthier S, Leguy-Seguin V, Martin L, Ciudad M, Samson M, Trad M, Lorcerie B, Janikashvili N, Saas P, Bonnotte B, Radstake TR. Audia S, et al. Blood. 2014 Oct 30;124(18):2858-66. doi: 10.1182/blood-2014-03-563445. Epub 2014 Sep 16. Blood. 2014. PMID: 25232056 Free article.
Association of MicroRNA-618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis.
Rossato M, Affandi AJ, Thordardottir S, Wichers CGK, Cossu M, Broen JCA, Moret FM, Bossini-Castillo L, Chouri E, van Bon L, Wolters F, Marut W, van der Kroef M, Silva-Cardoso S, Bekker CPJ, Dolstra H, van Laar JM, Martin J, van Roon JAG, Reedquist KA, Beretta L, Radstake TRDJ. Rossato M, et al. Among authors: wichers cgk. Arthritis Rheumatol. 2017 Sep;69(9):1891-1902. doi: 10.1002/art.40163. Epub 2017 Jul 25. Arthritis Rheumatol. 2017. PMID: 28556560 Free article.
Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosis.
Chouri E, Servaas NH, Bekker CPJ, Affandi AJ, Cossu M, Hillen MR, Angiolilli C, Mertens JS, van den Hoogen LL, Silva-Cardoso S, van der Kroef M, Vazirpanah N, Wichers CGK, Carvalheiro T, Blokland SLM, Giovannone B, Porretti L, Marut W, Vigone B, van Roon JAG, Beretta L, Rossato M, Radstake TRDJ. Chouri E, et al. Among authors: wichers cgk. J Autoimmun. 2018 May;89:162-170. doi: 10.1016/j.jaut.2017.12.015. Epub 2018 Jan 20. J Autoimmun. 2018. PMID: 29371048 Free article.
Galectin-9 is an easy to measure biomarker for the interferon signature in systemic lupus erythematosus and antiphospholipid syndrome.
van den Hoogen LL, van Roon JAG, Mertens JS, Wienke J, Lopes AP, de Jager W, Rossato M, Pandit A, Wichers CGK, van Wijk F, Fritsch-Stork RDE, Radstake TRDJ. van den Hoogen LL, et al. Among authors: wichers cgk. Ann Rheum Dis. 2018 Dec;77(12):1810-1814. doi: 10.1136/annrheumdis-2018-213497. Epub 2018 Sep 5. Ann Rheum Dis. 2018. PMID: 30185417
Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?
Blokland SLM, Hillen MR, Wichers CGK, Zimmermann M, Kruize AA, Radstake TRDJ, Broen JCA, van Roon JAG. Blokland SLM, et al. Among authors: wichers cgk. RMD Open. 2019 Jan 11;5(1):e000701. doi: 10.1136/rmdopen-2018-000701. eCollection 2019. RMD Open. 2019. PMID: 30713717 Free PMC article. No abstract available.
Histone modifications underlie monocyte dysregulation in patients with systemic sclerosis, underlining the treatment potential of epigenetic targeting.
van der Kroef M, Castellucci M, Mokry M, Cossu M, Garonzi M, Bossini-Castillo LM, Chouri E, Wichers CGK, Beretta L, Trombetta E, Silva-Cardoso S, Vazirpanah N, Carvalheiro T, Angiolilli C, Bekker CPJ, Affandi AJ, Reedquist KA, Bonte-Mineur F, Zirkzee EJM, Bazzoni F, Radstake TRDJ, Rossato M. van der Kroef M, et al. Among authors: wichers cgk. Ann Rheum Dis. 2019 Apr;78(4):529-538. doi: 10.1136/annrheumdis-2018-214295. Epub 2019 Feb 6. Ann Rheum Dis. 2019. PMID: 30793699
mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy?
Vazirpanah N, Ottria A, van der Linden M, Wichers CGK, Schuiveling M, van Lochem E, Phipps-Green A, Merriman T, Zimmermann M, Jansen M, Radstake TRDJ, Broen JCA. Vazirpanah N, et al. Among authors: wichers cgk. Ann Rheum Dis. 2019 May;78(5):663-671. doi: 10.1136/annrheumdis-2018-214656. Epub 2019 Feb 27. Ann Rheum Dis. 2019. PMID: 30814053
CXCL4 triggers monocytes and macrophages to produce PDGF-BB, culminating in fibroblast activation: Implications for systemic sclerosis.
van der Kroef M, Carvalheiro T, Rossato M, de Wit F, Cossu M, Chouri E, Wichers CGK, Bekker CPJ, Beretta L, Vazirpanah N, Trombetta E, Radstake TRDJ, Angiolilli C. van der Kroef M, et al. Among authors: wichers cgk. J Autoimmun. 2020 Jul;111:102444. doi: 10.1016/j.jaut.2020.102444. Epub 2020 Apr 10. J Autoimmun. 2020. PMID: 32284212 Free article.
23 results